Stroke prevention in the elderly atrial fibrillation patient with comorbid conditions: Focus on non-vitamin K antagonist oral anticoagulants

Mohit K. Turagam; Poonam Velagapudi; Greg C. Flaker

doi:10.2147/CIA.S80641

Stroke prevention in the elderly atrial fibrillation patient with comorbid conditions: Focus on non-vitamin K antagonist oral anticoagulants

Mohit K. Turagam, Poonam Velagapudi, Greg C. Flaker

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Stroke prevention in elderly atrial fibrillation patients remains a challenge. There is a high risk of stroke and systemic thromboembolism but also a high risk of bleeding if anticoagulants are prescribed. The elderly have increased chronic kidney disease, coronary artery disease, polypharmacy, and overall frailty. For all these reasons, anticoagulant use is underutilized in the elderly. In this manuscript, the benefits of non-vitamin K antagonist oral anticoagulants compared with warfarin in the elderly patient population with multiple comorbid conditions are reviewed.

Original language	English
Pages (from-to)	1431-1444
Number of pages	14
Journal	Clinical Interventions in Aging
Volume	10
DOIs	https://doi.org/10.2147/CIA.S80641
State	Published - 3 Sep 2015
Externally published	Yes

Keywords

Apixaban
Dabigatran
Edoxaban
Non-vitamin K antagonist oral anticoagulants
Novel oral anticoagulants
Rivaroxaban
Warfarin

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title = "Stroke prevention in the elderly atrial fibrillation patient with comorbid conditions: Focus on non-vitamin K antagonist oral anticoagulants",

abstract = "Stroke prevention in elderly atrial fibrillation patients remains a challenge. There is a high risk of stroke and systemic thromboembolism but also a high risk of bleeding if anticoagulants are prescribed. The elderly have increased chronic kidney disease, coronary artery disease, polypharmacy, and overall frailty. For all these reasons, anticoagulant use is underutilized in the elderly. In this manuscript, the benefits of non-vitamin K antagonist oral anticoagulants compared with warfarin in the elderly patient population with multiple comorbid conditions are reviewed.",

keywords = "Apixaban, Dabigatran, Edoxaban, Non-vitamin K antagonist oral anticoagulants, Novel oral anticoagulants, Rivaroxaban, Warfarin",

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AU - Turagam, Mohit K.

AU - Velagapudi, Poonam

AU - Flaker, Greg C.

PY - 2015/9/3

Y1 - 2015/9/3

N2 - Stroke prevention in elderly atrial fibrillation patients remains a challenge. There is a high risk of stroke and systemic thromboembolism but also a high risk of bleeding if anticoagulants are prescribed. The elderly have increased chronic kidney disease, coronary artery disease, polypharmacy, and overall frailty. For all these reasons, anticoagulant use is underutilized in the elderly. In this manuscript, the benefits of non-vitamin K antagonist oral anticoagulants compared with warfarin in the elderly patient population with multiple comorbid conditions are reviewed.

AB - Stroke prevention in elderly atrial fibrillation patients remains a challenge. There is a high risk of stroke and systemic thromboembolism but also a high risk of bleeding if anticoagulants are prescribed. The elderly have increased chronic kidney disease, coronary artery disease, polypharmacy, and overall frailty. For all these reasons, anticoagulant use is underutilized in the elderly. In this manuscript, the benefits of non-vitamin K antagonist oral anticoagulants compared with warfarin in the elderly patient population with multiple comorbid conditions are reviewed.

KW - Apixaban

KW - Dabigatran

KW - Edoxaban

KW - Non-vitamin K antagonist oral anticoagulants

KW - Novel oral anticoagulants

KW - Rivaroxaban

KW - Warfarin

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VL - 10

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JO - Clinical Interventions in Aging

JF - Clinical Interventions in Aging

ER -

Stroke prevention in the elderly atrial fibrillation patient with comorbid conditions: Focus on non-vitamin K antagonist oral anticoagulants

Abstract

Keywords

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