Stroke mechanisms and clinical presentation in large subcortical infarctions

Deborah R. Horowitz, Stanley Tuhrim

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Large subcortical infarctions may be due to cerebral embolism and cause cortical signs more frequently than small subcortical infarctions, which usually result from small-vessel disease and are not associated with cortical findings. We evaluated 51 consecutive patients with a subcortical infarct on CT that was 1.5 cm or larger for a potential carotid or cardiac source of embolism and determined how frequently aphasia, hemineglect, or gaze paresis occurred. A carotid or cardiac embolic source was identified in 63% of the total population with a carotid source occurring in 23% and a cardiac source occurring in 49%. More than one-half of the patients with hypertension or diabetes mellitus had an embolic source, whereas all patients without these risk factors had a possible carotid or cardiac source of embolism. Aphasia or hemineglect occurred in 39% of patients and gaze paresis occurred in 41%. Large subcortical strokes frequently result in a different clinical syndrome and from a different mechanism than small subcortical strokes.

Original languageEnglish
Pages (from-to)1538-1541
Number of pages4
JournalNeurology
Volume49
Issue number6
DOIs
StatePublished - Dec 1997

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