Stripe formation in the early fly embryo: Principles, models, and networks

Dmitri Papatsenko

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Early development of animal embryos begins from spatially distributed products of gene expression, i.e., gradients. While maternal and early zygotic genes form broad and/or terminal gradients, their direct targets appear later on as relatively narrow stripes, which fore-shadow presumptive germ layers or future segments. Evidently, stripe expression of the zygotic genes is among the key mechanisms of embryo patterning. In this paper, known qualitative and quantitative models for the stripe formation are considered on the example of early embryogenesis of Drosophila. The current model analysis emphasizes the role of spatial information flow in development. Discussion is given on frequent network motifs, pointing to spatial stripe formation solutions.

Original languageEnglish
Pages (from-to)1172-1180
Number of pages9
JournalBioEssays
Volume31
Issue number11
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Antagonistic gradients
  • Double repression
  • Drosophila embryo
  • Dual regulation
  • Stripe expression

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