Striatal morphology correlates with sensory abnormalities in unaffected relatives of cervical dystonia patients

Richard A. Walsh, Robert Whelan, John O'Dwyer, Sean O'Riordan, Siobhan Hutchinson, Risteard O'Laoide, Kevin Malone, Richard Reilly, Michael Hutchinson

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Structural grey matter abnormalities have been described in adult-onset primary torsion dystonia (AOPTD). Altered spatial discrimination thresholds are found in familial and sporadic AOPTD and in some unaffected relatives who may be non-manifesting gene carriers. Our hypothesis was that a subset of unaffected relatives with abnormal spatial acuity would have associated structural abnormalities. Twenty-eight unaffected relatives of patients with familial cervical dystonia, 24 relatives of patients with sporadic cervical dystonia and 27 control subjects were recruited. Spatial discrimination thresholds (SDTs) were determined using a grating orientation task. High-resolution magnetic resonance imaging (MRI) images (1.5 T) were analysed using voxel-based morphometry. Unaffected familial relatives with abnormal SDTs had reduced caudate grey matter volume (GMV) bilaterally relative to those with normal SDTs (right Z = 3.45, left Z = 3.81), where there was a negative correlation between SDTs and GMV (r = -0.76, r 2 = 0.58, p < 0.0001). Familial relatives also had bilateral sensory cortical expansion relative to unrelated controls (right Z = 4.02, left Z = 3.79). Unaffected relatives of patients with sporadic cervical dystonia who had abnormal SDTs had reduced putaminal GMV bilaterally compared with those with normal SDTs (right Z = 3.96, left Z = 3.45). Sensory abnormalities in some unaffected relatives correlate with a striatal substrate and may be a marker of genetic susceptibility in these individuals. Further investigation of grey matter changes as a candidate endophenotype may assist future genetic studies of dystonia.

Original languageEnglish
Pages (from-to)1307-1313
Number of pages7
JournalJournal of Neurology
Volume256
Issue number8
DOIs
StatePublished - Aug 2009
Externally publishedYes

Keywords

  • Basal ganglia
  • Dystonia
  • Spatial discrimination
  • Voxel-based morphometry

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