Striatal DOPAC elevation predicts antipsychotic efficacy of metoclopramide

Michael Stanley; Sherwin Wilk

doi:10.1016/0024-3205(79)90243-1

Striatal DOPAC elevation predicts antipsychotic efficacy of metoclopramide

Michael Stanley, Sherwin Wilk

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Antipsychotic drugs are known to elevate levels of 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum in a characteristic fashion. We have found that the two benzamide derivatives sulpiride (an atypical antipsychotic drug) and metoclopramide (a compound believed to have no antipsychotic activity) produce a dose-dependent elevation of striatal DOPAC that is similar to known antipsychotic drugs. We have found the potency of metoclopramide to be similar to that of chlorpromazine. Based on these findings we predict that metoclopramide will display antipsychotic efficacy at a dose range similar to chlorpromazine. The inconsistent effects of metoclopramide and sulpiride in a number of preclinical and clinical studies are discussed.

Original language	English
Pages (from-to)	1907-1912
Number of pages	6
Journal	Life Sciences
Volume	24
Issue number	20
DOIs	https://doi.org/10.1016/0024-3205(79)90243-1
State	Published - 14 May 1979

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title = "Striatal DOPAC elevation predicts antipsychotic efficacy of metoclopramide",

abstract = "Antipsychotic drugs are known to elevate levels of 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum in a characteristic fashion. We have found that the two benzamide derivatives sulpiride (an atypical antipsychotic drug) and metoclopramide (a compound believed to have no antipsychotic activity) produce a dose-dependent elevation of striatal DOPAC that is similar to known antipsychotic drugs. We have found the potency of metoclopramide to be similar to that of chlorpromazine. Based on these findings we predict that metoclopramide will display antipsychotic efficacy at a dose range similar to chlorpromazine. The inconsistent effects of metoclopramide and sulpiride in a number of preclinical and clinical studies are discussed.",

author = "Michael Stanley and Sherwin Wilk",

note = "Funding Information: We thank Dr . Ionel Rudic for expert technical supported by Grant 21638-07 from the NIM{\"U} .",

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T1 - Striatal DOPAC elevation predicts antipsychotic efficacy of metoclopramide

AU - Stanley, Michael

AU - Wilk, Sherwin

N1 - Funding Information: We thank Dr . Ionel Rudic for expert technical supported by Grant 21638-07 from the NIMÜ .

PY - 1979/5/14

Y1 - 1979/5/14

N2 - Antipsychotic drugs are known to elevate levels of 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum in a characteristic fashion. We have found that the two benzamide derivatives sulpiride (an atypical antipsychotic drug) and metoclopramide (a compound believed to have no antipsychotic activity) produce a dose-dependent elevation of striatal DOPAC that is similar to known antipsychotic drugs. We have found the potency of metoclopramide to be similar to that of chlorpromazine. Based on these findings we predict that metoclopramide will display antipsychotic efficacy at a dose range similar to chlorpromazine. The inconsistent effects of metoclopramide and sulpiride in a number of preclinical and clinical studies are discussed.

AB - Antipsychotic drugs are known to elevate levels of 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum in a characteristic fashion. We have found that the two benzamide derivatives sulpiride (an atypical antipsychotic drug) and metoclopramide (a compound believed to have no antipsychotic activity) produce a dose-dependent elevation of striatal DOPAC that is similar to known antipsychotic drugs. We have found the potency of metoclopramide to be similar to that of chlorpromazine. Based on these findings we predict that metoclopramide will display antipsychotic efficacy at a dose range similar to chlorpromazine. The inconsistent effects of metoclopramide and sulpiride in a number of preclinical and clinical studies are discussed.

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JO - Life Sciences

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Striatal DOPAC elevation predicts antipsychotic efficacy of metoclopramide

Abstract

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