TY - JOUR
T1 - Stress Molecular Signaling in Interaction With Cognition
AU - Lugenbühl, Justina F.
AU - Viho, Eva M.G.
AU - Binder, Elisabeth B.
AU - Daskalakis, Nikolaos P.
N1 - Publisher Copyright:
© 2024 Society of Biological Psychiatry
PY - 2024
Y1 - 2024
N2 - Exposure to stressful life events is associated with a high risk of developing psychiatric disorders with a wide variety of symptoms. Cognitive symptoms in stress-related psychiatric disorders can be particularly challenging to understand, both for those experiencing them and for health care providers. To gain insights, it is important to capture stress-induced structural, epigenomic, transcriptomic, and proteomic changes in relevant brain regions such as the amygdala, hippocampus, locus coeruleus, and prefrontal cortex that result in long-lasting alterations in brain function. In this review, we will emphasize a subset of stress molecular mechanisms that alter neuroplasticity, neurogenesis, and balance between excitatory and inhibitory neurons. Then, we discuss how to identify genetic risk factors that may accelerate stress-driven or stress-induced cognitive impairment. Despite the development of new technologies such as single-cell resolution sequencing, our understanding of the molecular effects of stress in the brain remains to be deepened. A better understanding of the diversity of stress effects in different brain regions and cell types is a prerequisite to open new avenues for mechanism-informed prevention and treatment of stress-related cognitive symptoms.
AB - Exposure to stressful life events is associated with a high risk of developing psychiatric disorders with a wide variety of symptoms. Cognitive symptoms in stress-related psychiatric disorders can be particularly challenging to understand, both for those experiencing them and for health care providers. To gain insights, it is important to capture stress-induced structural, epigenomic, transcriptomic, and proteomic changes in relevant brain regions such as the amygdala, hippocampus, locus coeruleus, and prefrontal cortex that result in long-lasting alterations in brain function. In this review, we will emphasize a subset of stress molecular mechanisms that alter neuroplasticity, neurogenesis, and balance between excitatory and inhibitory neurons. Then, we discuss how to identify genetic risk factors that may accelerate stress-driven or stress-induced cognitive impairment. Despite the development of new technologies such as single-cell resolution sequencing, our understanding of the molecular effects of stress in the brain remains to be deepened. A better understanding of the diversity of stress effects in different brain regions and cell types is a prerequisite to open new avenues for mechanism-informed prevention and treatment of stress-related cognitive symptoms.
KW - Cognition
KW - Epigenetic
KW - Genetics
KW - Sequencing
KW - Stress
KW - Synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=85209718028&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2024.09.023
DO - 10.1016/j.biopsych.2024.09.023
M3 - Review article
C2 - 39368530
AN - SCOPUS:85209718028
SN - 0006-3223
VL - 97
SP - 349
EP - 358
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 4
ER -