Stress-Associated Neurobiological Pathway Linking Socioeconomic Disparities to Cardiovascular Disease

Ahmed Tawakol, Michael T. Osborne, Ying Wang, Basma Hammed, Brian Tung, Tomas Patrich, Blake Oberfeld, Amorina Ishai, Lisa M. Shin, Matthias Nahrendorf, Erica T. Warner, Jason Wasfy, Zahi A. Fayad, Karestan Koenen, Paul M. Ridker, Roger K. Pitman, Katrina A. Armstrong

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

Background: Lower socioeconomic status (SES) associates with a higher risk of major adverse cardiac events (MACE) via mechanisms that are not well understood. Objectives: Because psychosocial stress is more prevalent among those with low SES, this study tested the hypothesis that stress-associated neurobiological pathways involving up-regulated inflammation in part mediate the link between lower SES and MACE. Methods: A total of 509 individuals, median age 55 years (interquartile range: 45 to 66 years), underwent clinically indicated whole-body 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging and met pre-defined inclusion criteria, including absence of known cardiovascular disease or active cancer. Baseline hematopoietic tissue activity, arterial inflammation, and in a subset of 289, resting amygdalar metabolism (a measure of stress-associated neural activity) were quantified using validated 18F-fluorodeoxyglucose positron emission tomography/computed tomography methods. SES was captured by neighborhood SES factors (e.g., median household income and crime). MACE within 5 years of imaging was adjudicated. Results: Over a median 4.0 years, 40 individuals experienced MACE. Baseline income inversely associated with amygdalar activity (standardized β: −0.157 [95% confidence interval (CI): −0.266 to −0.041]; p = 0.007) and arterial inflammation (β: −0.10 [95% CI: −0.18 to −0.14]; p = 0.022). Further, income associated with subsequent MACE (standardized hazard ratio: 0.67 [95% CI: 0.47 to 0.96]; p = 0.029) after multivariable adjustments. Mediation analysis demonstrated that the path of: ↓ neighborhood income to ↑ amygdalar activity to ↑ bone marrow activity to ↑ arterial inflammation to ↑ MACE was significant (β: −0.01 [95% CI: −0.06 to −0.001]; p < 0.05). Conclusions: Lower SES: 1) associates with higher amygdalar activity; and 2) independently predicts MACE via a serial pathway that includes higher amygdalar activity, bone marrow activity, and arterial inflammation. These findings illuminate a stress-associated neurobiological mechanism by which SES disparities may potentiate adverse health outcomes.

Original languageEnglish
Pages (from-to)3243-3255
Number of pages13
JournalJournal of the American College of Cardiology
Volume73
Issue number25
DOIs
StatePublished - 2 Jul 2019

Keywords

  • cardiovascular disease
  • neurobiology
  • positron emission tomography
  • socioeconomic disparities
  • stress

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