Strategies for the development of metalloimmunotherapies

Xiaoqi Sun; Xingwu Zhou; Xiaoyue Shi; Omar A. Abed; Xinran An; Yu Leo Lei; James J. Moon

doi:10.1038/s41551-024-01221-7

Strategies for the development of metalloimmunotherapies

Xiaoqi Sun, Xingwu Zhou, Xiaoyue Shi, Omar A. Abed, Xinran An, Yu Leo Lei, James J. Moon

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies. By examining how metal ions modulate the innate and adaptive immune systems, as well as host–microbiota interactions, we discuss strategies for the development of such metalloimmunotherapies for the treatment of cancer and other immune-related diseases.

Original language	English
Pages (from-to)	1073-1091
Number of pages	19
Journal	Nature Biomedical Engineering
Volume	8
Issue number	9
DOIs	https://doi.org/10.1038/s41551-024-01221-7
State	Published - Sep 2024
Externally published	Yes

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title = "Strategies for the development of metalloimmunotherapies",

abstract = "Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies. By examining how metal ions modulate the innate and adaptive immune systems, as well as host–microbiota interactions, we discuss strategies for the development of such metalloimmunotherapies for the treatment of cancer and other immune-related diseases.",

author = "Xiaoqi Sun and Xingwu Zhou and Xiaoyue Shi and Abed, {Omar A.} and Xinran An and Lei, {Yu Leo} and Moon, {James J.}",

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AU - Sun, Xiaoqi

AU - Zhou, Xingwu

AU - Shi, Xiaoyue

AU - Abed, Omar A.

AU - An, Xinran

AU - Lei, Yu Leo

AU - Moon, James J.

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AB - Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies. By examining how metal ions modulate the innate and adaptive immune systems, as well as host–microbiota interactions, we discuss strategies for the development of such metalloimmunotherapies for the treatment of cancer and other immune-related diseases.

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JO - Nature Biomedical Engineering

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Strategies for the development of metalloimmunotherapies

Abstract

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