Strategies for enrichment and selection of stem cell-derived tissue precursors

Harold S. Bernstein; William C. Hyun

doi:10.1186/scrt108

Strategies for enrichment and selection of stem cell-derived tissue precursors

Harold S. Bernstein, William C. Hyun

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Human embryonic stem cells have the capacity for self-renewal and pluripotency and thus are a primary candidate for tissue engineering and regenerative therapies. These cells also provide an opportunity to study the development of human tissues ex vivo. To date, numerous human embryonic stem cell lines have been derived and characterized. In this review, we will detail the strategies used to direct tissue-specific differentiation of embryonic stem cells. We also will discuss how these strategies have produced new sources of tissue-specific progenitor cells. Finally, we will describe the next generation of methods being developed to identify and select stem cell-derived tissue precursors for experimental study and clinical use.

Original language	English
Article number	17
Journal	Stem Cell Research and Therapy
Volume	3
Issue number	3
DOIs	https://doi.org/10.1186/scrt108
State	Published - 2012
Externally published	Yes

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title = "Strategies for enrichment and selection of stem cell-derived tissue precursors",

abstract = "Human embryonic stem cells have the capacity for self-renewal and pluripotency and thus are a primary candidate for tissue engineering and regenerative therapies. These cells also provide an opportunity to study the development of human tissues ex vivo. To date, numerous human embryonic stem cell lines have been derived and characterized. In this review, we will detail the strategies used to direct tissue-specific differentiation of embryonic stem cells. We also will discuss how these strategies have produced new sources of tissue-specific progenitor cells. Finally, we will describe the next generation of methods being developed to identify and select stem cell-derived tissue precursors for experimental study and clinical use.",

author = "Bernstein, {Harold S.} and Hyun, {William C.}",

note = "Funding Information: HSB is supported by grants from the National Heart, Lung, and Blood Institute; the California Institute for Regenerative Medicine; and the Muscular Dystrophy Association. WCH is supported by funds from the UCSF Helen Diller Family Comprehensive Cancer Center Laboratory for Cell Analysis and the National Cancer Institute.",

year = "2012",

doi = "10.1186/scrt108",

language = "English",

volume = "3",

journal = "Stem Cell Research and Therapy",

issn = "1757-6512",

publisher = "BioMed Central Ltd.",

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T1 - Strategies for enrichment and selection of stem cell-derived tissue precursors

AU - Bernstein, Harold S.

AU - Hyun, William C.

N1 - Funding Information: HSB is supported by grants from the National Heart, Lung, and Blood Institute; the California Institute for Regenerative Medicine; and the Muscular Dystrophy Association. WCH is supported by funds from the UCSF Helen Diller Family Comprehensive Cancer Center Laboratory for Cell Analysis and the National Cancer Institute.

PY - 2012

Y1 - 2012

N2 - Human embryonic stem cells have the capacity for self-renewal and pluripotency and thus are a primary candidate for tissue engineering and regenerative therapies. These cells also provide an opportunity to study the development of human tissues ex vivo. To date, numerous human embryonic stem cell lines have been derived and characterized. In this review, we will detail the strategies used to direct tissue-specific differentiation of embryonic stem cells. We also will discuss how these strategies have produced new sources of tissue-specific progenitor cells. Finally, we will describe the next generation of methods being developed to identify and select stem cell-derived tissue precursors for experimental study and clinical use.

AB - Human embryonic stem cells have the capacity for self-renewal and pluripotency and thus are a primary candidate for tissue engineering and regenerative therapies. These cells also provide an opportunity to study the development of human tissues ex vivo. To date, numerous human embryonic stem cell lines have been derived and characterized. In this review, we will detail the strategies used to direct tissue-specific differentiation of embryonic stem cells. We also will discuss how these strategies have produced new sources of tissue-specific progenitor cells. Finally, we will describe the next generation of methods being developed to identify and select stem cell-derived tissue precursors for experimental study and clinical use.

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DO - 10.1186/scrt108

M3 - Review article

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AN - SCOPUS:84860816712

SN - 1757-6512

VL - 3

JO - Stem Cell Research and Therapy

JF - Stem Cell Research and Therapy

IS - 3

M1 - 17

ER -

Strategies for enrichment and selection of stem cell-derived tissue precursors

Abstract

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