TY - GEN
T1 - Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves
AU - Tuan, Hoang Trong Minh
AU - Williams, George S.B.
AU - Chikando, Aristide C.
AU - Sobie, Eric A.
AU - Lederer, W. Jonathan
AU - Jafri, M. Saleet
PY - 2011
Y1 - 2011
N2 - A three dimensional model of calcium dynamics in the rat ventricular myocyte was developed to study the mechanism of calcium homeostasis and pathological calcium dynamics during calcium overload. The model contains 20,000 calcium release units (CRUs) each containing 49 ryanodine receptors. The model simulates calcium sparks with a realistic spontaneous calcium spark rate. It suggests that in addition to the calcium spark-based leak, there is an invisible calcium leak caused by the stochastic opening of a small number of ryanodine receptors in each CRU without triggering a calcium spark. The model also explores the mechanism of calcium wave propagation between release sites under the conditions of calcium overload.
AB - A three dimensional model of calcium dynamics in the rat ventricular myocyte was developed to study the mechanism of calcium homeostasis and pathological calcium dynamics during calcium overload. The model contains 20,000 calcium release units (CRUs) each containing 49 ryanodine receptors. The model simulates calcium sparks with a realistic spontaneous calcium spark rate. It suggests that in addition to the calcium spark-based leak, there is an invisible calcium leak caused by the stochastic opening of a small number of ryanodine receptors in each CRU without triggering a calcium spark. The model also explores the mechanism of calcium wave propagation between release sites under the conditions of calcium overload.
UR - http://www.scopus.com/inward/record.url?scp=84863572611&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2011.6091158
DO - 10.1109/IEMBS.2011.6091158
M3 - Conference contribution
C2 - 22255381
AN - SCOPUS:84863572611
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 4677
EP - 4680
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -