Abstract

Background: Emerging evidence suggests that STK11 mutations may influence clinical outcome and response to immunotherapy in cancer. Materials and methods: Next-generation targeted sequencing of STK11 mutation status in a large cohort of 188 meningiomas. Results: STK11 loss-of-function mutations were identified in 3.7% of meningiomas. STK11 mutations were found in both low- and high-grade lesions and samples from primary and recurrent disease. There was a 2.8-fold increased risk of death for patients whose meningioma harbored an STK11 mutation, after controlling for lesion grade and occurrence status. The median overall survival for patients with STK11-mutated meningiomas was 4.4 years compared with 16.8 years. Conclusion: These data identify recurrent STK11 mutations in a subset of meningiomas. Genotyping of STK11 is encouraged for meningioma patients undergoing immunotherapy-based therapy.

Original languageEnglish
Pages (from-to)2585-2589
Number of pages5
JournalNeurological Sciences
Volume41
Issue number9
DOIs
StatePublished - 1 Sep 2020

Keywords

  • Central nervous system
  • Meningioma
  • Neurooncology
  • STK11
  • Sequencing

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