Abstract
Membranes and solubilized, reconstituted membranes from Moloney-infected tumors MBL-2 have been used to stimulate in vitro secondary cytolytic T lymphocytes (CTL) in C57BL/6 mice primed with Moloney murine sarcoma virus. Membranes are shown to stimulate the generation of Moloney-specific and H-2 restricted CTL. Stimulation with solubilized, reconstituted membranes required the presence of rat lymphocyte Con A supernatant (containing interleukin 2) during culture. Reconstituted membranes made in the presence of a detergent-insoluble fraction from the plasma membrane were able to stimulate a response in the absence of Con A supernatant.
| Original language | English |
|---|---|
| Pages (from-to) | 493-495 |
| Number of pages | 3 |
| Journal | Journal of Immunology |
| Volume | 130 |
| Issue number | 1 |
| State | Published - 1983 |
| Externally published | Yes |