Stimulation of lung lysyl oxidase activity in hamsters with elastase-induced emphysema

M. Osman; R. R.J. Kaldany; J. O. Cantor; G. M. Turino; I. Mandl

Stimulation of lung lysyl oxidase activity in hamsters with elastase-induced emphysema

M. Osman
, R. R.J. Kaldany
, J. O. Cantor
, G. M. Turino
, I. Mandl

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Lysyl oxidase activity was measured in lung extracts of hamsters with elastase-induced emphysema 8 days after administration of the enzyme and again after 2, 3, and 4 wk. Levels of activity rose rapidly to 7 times the base values determined in the lungs of saline-induced control animals. In parallel with the increase in lysyl oxidase activity, the rate of ¹⁴C-lysine incorporation into desmosine and isodesmosine was at its maximum 1 wk after elastase administration, reflecting the lysyl-oxidase-mediated cross-link formation, which is the final step in the resynthesis of the pulmonary elastin destroyed by the elastolytic insult.

Original language	English
Pages (from-to)	169-170
Number of pages	2
Journal	American Review of Respiratory Disease
Volume	131
Issue number	1
State	Published - 1985

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title = "Stimulation of lung lysyl oxidase activity in hamsters with elastase-induced emphysema",

abstract = "Lysyl oxidase activity was measured in lung extracts of hamsters with elastase-induced emphysema 8 days after administration of the enzyme and again after 2, 3, and 4 wk. Levels of activity rose rapidly to 7 times the base values determined in the lungs of saline-induced control animals. In parallel with the increase in lysyl oxidase activity, the rate of 14C-lysine incorporation into desmosine and isodesmosine was at its maximum 1 wk after elastase administration, reflecting the lysyl-oxidase-mediated cross-link formation, which is the final step in the resynthesis of the pulmonary elastin destroyed by the elastolytic insult.",

author = "M. Osman and Kaldany, \{R. R.J.\} and Cantor, \{J. O.\} and Turino, \{G. M.\} and I. Mandl",

year = "1985",

language = "English",

volume = "131",

pages = "169--170",

journal = "American Review of Respiratory Disease",

issn = "0003-0805",

publisher = "American Thoracic Society",

number = "1",

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T1 - Stimulation of lung lysyl oxidase activity in hamsters with elastase-induced emphysema

AU - Osman, M.

AU - Kaldany, R. R.J.

AU - Cantor, J. O.

AU - Turino, G. M.

AU - Mandl, I.

PY - 1985

Y1 - 1985

N2 - Lysyl oxidase activity was measured in lung extracts of hamsters with elastase-induced emphysema 8 days after administration of the enzyme and again after 2, 3, and 4 wk. Levels of activity rose rapidly to 7 times the base values determined in the lungs of saline-induced control animals. In parallel with the increase in lysyl oxidase activity, the rate of 14C-lysine incorporation into desmosine and isodesmosine was at its maximum 1 wk after elastase administration, reflecting the lysyl-oxidase-mediated cross-link formation, which is the final step in the resynthesis of the pulmonary elastin destroyed by the elastolytic insult.

AB - Lysyl oxidase activity was measured in lung extracts of hamsters with elastase-induced emphysema 8 days after administration of the enzyme and again after 2, 3, and 4 wk. Levels of activity rose rapidly to 7 times the base values determined in the lungs of saline-induced control animals. In parallel with the increase in lysyl oxidase activity, the rate of 14C-lysine incorporation into desmosine and isodesmosine was at its maximum 1 wk after elastase administration, reflecting the lysyl-oxidase-mediated cross-link formation, which is the final step in the resynthesis of the pulmonary elastin destroyed by the elastolytic insult.

UR - https://www.scopus.com/pages/publications/0022001238

M3 - Article

C2 - 2857074

AN - SCOPUS:0022001238

SN - 0003-0805

VL - 131

SP - 169

EP - 170

JO - American Review of Respiratory Disease

JF - American Review of Respiratory Disease

IS - 1

ER -

Stimulation of lung lysyl oxidase activity in hamsters with elastase-induced emphysema

Abstract

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