Stevens-Johnson syndrome/toxic epidermal necrolysis in a patient receiving concurrent radiation and qemcitabine

Karen R. Sommers; Kevin M. Kong; Dang T. Bui; John P. Fruehauf; Randall F. Holcombe

doi:10.1097/00001813-200309000-00012

Stevens-Johnson syndrome/toxic epidermal necrolysis in a patient receiving concurrent radiation and qemcitabine

Karen R. Sommers
, Kevin M. Kong
, Dang T. Bui
, John P. Fruehauf
, Randall F. Holcombe

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

A patient with stage IV malignant melanoma treated with daily radiotherapy and low-dose (100 mg/m²) daily gemcitabine developed a blistering skin eruption, fever and neutropenia consistent with overlap Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). The diagnosis was confirmed by skin biopsy of an affected area. The case history is described, and the literature relating to the development of SJS/TEN in association with chemotherapy and radiotherapy administration is reviewed. This report describes a serious potential complication of concurrent gemcitabine and radiotherapy.

Original language	English
Pages (from-to)	659-662
Number of pages	4
Journal	Anti-Cancer Drugs
Volume	14
Issue number	8
DOIs	https://doi.org/10.1097/00001813-200309000-00012
State	Published - Sep 2003
Externally published	Yes

Keywords

Chemotherapy toxicity
Gemcitabine
Radiation
Stevens-Johnson Syndrome
Toxic epidermal necrolysis

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10.1097/00001813-200309000-00012

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title = "Stevens-Johnson syndrome/toxic epidermal necrolysis in a patient receiving concurrent radiation and qemcitabine",

abstract = "A patient with stage IV malignant melanoma treated with daily radiotherapy and low-dose (100 mg/m2) daily gemcitabine developed a blistering skin eruption, fever and neutropenia consistent with overlap Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). The diagnosis was confirmed by skin biopsy of an affected area. The case history is described, and the literature relating to the development of SJS/TEN in association with chemotherapy and radiotherapy administration is reviewed. This report describes a serious potential complication of concurrent gemcitabine and radiotherapy.",

keywords = "Chemotherapy toxicity, Gemcitabine, Radiation, Stevens-Johnson Syndrome, Toxic epidermal necrolysis",

author = "Sommers, \{Karen R.\} and Kong, \{Kevin M.\} and Bui, \{Dang T.\} and Fruehauf, \{John P.\} and Holcombe, \{Randall F.\}",

year = "2003",

month = sep,

doi = "10.1097/00001813-200309000-00012",

language = "English",

volume = "14",

pages = "659--662",

journal = "Anti-Cancer Drugs",

issn = "0959-4973",

publisher = "Lippincott Williams and Wilkins",

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}

TY - JOUR

T1 - Stevens-Johnson syndrome/toxic epidermal necrolysis in a patient receiving concurrent radiation and qemcitabine

AU - Sommers, Karen R.

AU - Kong, Kevin M.

AU - Bui, Dang T.

AU - Fruehauf, John P.

AU - Holcombe, Randall F.

PY - 2003/9

Y1 - 2003/9

N2 - A patient with stage IV malignant melanoma treated with daily radiotherapy and low-dose (100 mg/m2) daily gemcitabine developed a blistering skin eruption, fever and neutropenia consistent with overlap Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). The diagnosis was confirmed by skin biopsy of an affected area. The case history is described, and the literature relating to the development of SJS/TEN in association with chemotherapy and radiotherapy administration is reviewed. This report describes a serious potential complication of concurrent gemcitabine and radiotherapy.

AB - A patient with stage IV malignant melanoma treated with daily radiotherapy and low-dose (100 mg/m2) daily gemcitabine developed a blistering skin eruption, fever and neutropenia consistent with overlap Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). The diagnosis was confirmed by skin biopsy of an affected area. The case history is described, and the literature relating to the development of SJS/TEN in association with chemotherapy and radiotherapy administration is reviewed. This report describes a serious potential complication of concurrent gemcitabine and radiotherapy.

KW - Chemotherapy toxicity

KW - Gemcitabine

KW - Radiation

KW - Stevens-Johnson Syndrome

KW - Toxic epidermal necrolysis

UR - https://www.scopus.com/pages/publications/0142093201

U2 - 10.1097/00001813-200309000-00012

DO - 10.1097/00001813-200309000-00012

M3 - Article

C2 - 14501389

AN - SCOPUS:0142093201

SN - 0959-4973

VL - 14

SP - 659

EP - 662

JO - Anti-Cancer Drugs

JF - Anti-Cancer Drugs

IS - 8

ER -

Stevens-Johnson syndrome/toxic epidermal necrolysis in a patient receiving concurrent radiation and qemcitabine

Abstract

Keywords

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