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Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups
Kyle V. Butler
, Rong He
, Kathryn McLaughlin
, Giulio Vistoli
, Brett Langley
, Alan P. Kozikowski
Research output
:
Contribution to journal
›
Article
›
peer-review
8
Scopus citations
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Keyphrases
Histone Deacetylase Inhibitor (HDACi)
100%
Cysteine
100%
Stereoselectivity
100%
Zinc-binding Group
100%
Cell Death
25%
Clinical Trials
12%
Oxidative Stress
12%
Neurodegeneration
12%
Near-complete
12%
Small Molecules
12%
Multiple Mechanisms
12%
Stress-induced
12%
IC50 Value
12%
Complete Protection
12%
Histone Deacetylase 1 (HDAC1)
12%
Inhibitory Activity
12%
Neurotoxicity
12%
Neuroprotective
12%
Inhibition Assay
12%
Molecular Modeling
12%
Cellular Assay
12%
Hydroxamic Acid
12%
Enantiomeric
12%
Neuroprotection Assay
12%
Cysteine Derivatives
12%
Chemistry
Cysteine
100%
Histone
100%
histone deacetylase inhibitor
60%
Cell Death
40%
Enantiomer
40%
IC50
20%
Neurotoxicity
20%
Neuroprotective
20%
D-Cysteine Derivative
20%
L-Cysteine Derivative
20%
Hydroxamic Acid
20%
D-Cysteine
20%
L-Cysteine
20%
Oxidative Stress
20%
Molecular Model
20%
Nerve Degeneration
20%
Neurodegeneration
20%
Neuroprotection
20%
Pharmacology, Toxicology and Pharmaceutical Science
Cysteine
100%
Histone Deacetylase
100%
Histone Deacetylase Inhibitor
42%
Clinical Trial
14%
IC50
14%
Nerve Degeneration
14%
Neurotoxicity
14%
Neuroprotective Agent
14%
Neuroprotection
14%
Hydroxamic Acid
14%
Biochemistry, Genetics and Molecular Biology
Histone Deacetylase
100%
Cysteine
100%
Cell Death
28%
Clinical Trial
14%
Oxidative Stress
14%
Small Molecule
14%
Isoform
14%
Molecular Model
14%
IC50
14%
Enantiomer
14%
Veterinary Science and Veterinary Medicine
Small Molecule
100%
Oxidative Stress
100%