Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease?

Roger A. Barker; Anders Björklund; Steven J. Frucht; Clive N. Svendsen

doi:10.3233/JPD-219008

Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease?

Roger A. Barker, Anders Björklund, Steven J. Frucht, Clive N. Svendsen

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. In this debate, we discuss which of these approaches will evolve to be the treatment of choice for Parkinsonian patients in the future.

Original language	English
Pages (from-to)	909-917
Number of pages	9
Journal	Journal of Parkinson's Disease
Volume	11
Issue number	3
DOIs	https://doi.org/10.3233/JPD-219008
State	Published - 2021
Externally published	Yes

Keywords

DBS
Stem cells
brain repair
dopamine neurons

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10.3233/JPD-219008

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title = "Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease?",

abstract = "The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. In this debate, we discuss which of these approaches will evolve to be the treatment of choice for Parkinsonian patients in the future.",

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AU - Svendsen, Clive N.

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AB - The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. In this debate, we discuss which of these approaches will evolve to be the treatment of choice for Parkinsonian patients in the future.

KW - DBS

KW - Stem cells

KW - brain repair

KW - dopamine neurons

UR - https://www.scopus.com/pages/publications/85112139016

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Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease?

Abstract

Keywords

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