Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease?

Roger A. Barker, Anders Björklund, Steven J. Frucht, Clive N. Svendsen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. In this debate, we discuss which of these approaches will evolve to be the treatment of choice for Parkinsonian patients in the future.

Original languageEnglish
Pages (from-to)909-917
Number of pages9
JournalJournal of Parkinson's Disease
Volume11
Issue number3
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • DBS
  • Stem cells
  • brain repair
  • dopamine neurons

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