Status epilepticus-induced hyperemia and brain tissue hypoxia after cardiac arrest

Sang Bae Ko, Santiago Ortega-Gutierrez, H. Alex Choi, Jan Claassen, Mary Presciutti, J. Michael Schmidt, Neeraj Badjatia, Kiwon Lee, Stephan A. Mayer

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Objective: To report changes of cerebral blood flow and metabolism associated with status epilepticus after cardiacarrest. Design: Case report. Setting: Neurological intensive care unit in a university hospital. Patient: An 85-year-old man resuscitated from out-of-hospital cardiac arrest underwent brain multimodality monitoring and treatment with therapeutic hypothermia. Main Outcome Measures: Changes of cerebral blood flow and metabolism. Results: Repetitive electrographic seizure activity detected at the start of monitoring was associated with dramatic reductions in brain tissue oxygen tension and striking surges in cerebral blood flow and brain temperature. Intravenous lorazepam and levetiracetam administration resulted in immediate cessation of the seizures and these associated derangements. The lactate to pyruvate ratio was initially elevated and trended down after administration of anticonvulsants. Conclusion: Brain multimodality monitoring is a feasible method for evaluating secondary brain injury associated with seizure activity after cardiac arrest.

Original languageEnglish
Pages (from-to)1321-1324
Number of pages4
JournalArchives of Neurology
Issue number10
StatePublished - Oct 2011
Externally publishedYes


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