Status epilepticus-induced hyperemia and brain tissue hypoxia after cardiac arrest

Sang Bae Ko; Santiago Ortega-Gutierrez; H. Alex Choi; Jan Claassen; Mary Presciutti; J. Michael Schmidt; Neeraj Badjatia; Kiwon Lee; Stephan A. Mayer

doi:10.1001/archneurol.2011.240

Status epilepticus-induced hyperemia and brain tissue hypoxia after cardiac arrest

Sang Bae Ko, Santiago Ortega-Gutierrez, H. Alex Choi, Jan Claassen, Mary Presciutti, J. Michael Schmidt, Neeraj Badjatia, Kiwon Lee, Stephan A. Mayer

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Objective: To report changes of cerebral blood flow and metabolism associated with status epilepticus after cardiacarrest. Design: Case report. Setting: Neurological intensive care unit in a university hospital. Patient: An 85-year-old man resuscitated from out-of-hospital cardiac arrest underwent brain multimodality monitoring and treatment with therapeutic hypothermia. Main Outcome Measures: Changes of cerebral blood flow and metabolism. Results: Repetitive electrographic seizure activity detected at the start of monitoring was associated with dramatic reductions in brain tissue oxygen tension and striking surges in cerebral blood flow and brain temperature. Intravenous lorazepam and levetiracetam administration resulted in immediate cessation of the seizures and these associated derangements. The lactate to pyruvate ratio was initially elevated and trended down after administration of anticonvulsants. Conclusion: Brain multimodality monitoring is a feasible method for evaluating secondary brain injury associated with seizure activity after cardiac arrest.

Original language	English
Pages (from-to)	1321-1324
Number of pages	4
Journal	Archives of Neurology
Volume	68
Issue number	10
DOIs	https://doi.org/10.1001/archneurol.2011.240
State	Published - Oct 2011
Externally published	Yes

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title = "Status epilepticus-induced hyperemia and brain tissue hypoxia after cardiac arrest",

abstract = "Objective: To report changes of cerebral blood flow and metabolism associated with status epilepticus after cardiacarrest. Design: Case report. Setting: Neurological intensive care unit in a university hospital. Patient: An 85-year-old man resuscitated from out-of-hospital cardiac arrest underwent brain multimodality monitoring and treatment with therapeutic hypothermia. Main Outcome Measures: Changes of cerebral blood flow and metabolism. Results: Repetitive electrographic seizure activity detected at the start of monitoring was associated with dramatic reductions in brain tissue oxygen tension and striking surges in cerebral blood flow and brain temperature. Intravenous lorazepam and levetiracetam administration resulted in immediate cessation of the seizures and these associated derangements. The lactate to pyruvate ratio was initially elevated and trended down after administration of anticonvulsants. Conclusion: Brain multimodality monitoring is a feasible method for evaluating secondary brain injury associated with seizure activity after cardiac arrest.",

author = "Ko, {Sang Bae} and Santiago Ortega-Gutierrez and Choi, {H. Alex} and Jan Claassen and Mary Presciutti and Schmidt, {J. Michael} and Neeraj Badjatia and Kiwon Lee and Mayer, {Stephan A.}",

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AU - Ko, Sang Bae

AU - Ortega-Gutierrez, Santiago

AU - Choi, H. Alex

AU - Claassen, Jan

AU - Presciutti, Mary

AU - Schmidt, J. Michael

AU - Badjatia, Neeraj

AU - Lee, Kiwon

AU - Mayer, Stephan A.

PY - 2011/10

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AB - Objective: To report changes of cerebral blood flow and metabolism associated with status epilepticus after cardiacarrest. Design: Case report. Setting: Neurological intensive care unit in a university hospital. Patient: An 85-year-old man resuscitated from out-of-hospital cardiac arrest underwent brain multimodality monitoring and treatment with therapeutic hypothermia. Main Outcome Measures: Changes of cerebral blood flow and metabolism. Results: Repetitive electrographic seizure activity detected at the start of monitoring was associated with dramatic reductions in brain tissue oxygen tension and striking surges in cerebral blood flow and brain temperature. Intravenous lorazepam and levetiracetam administration resulted in immediate cessation of the seizures and these associated derangements. The lactate to pyruvate ratio was initially elevated and trended down after administration of anticonvulsants. Conclusion: Brain multimodality monitoring is a feasible method for evaluating secondary brain injury associated with seizure activity after cardiac arrest.

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Status epilepticus-induced hyperemia and brain tissue hypoxia after cardiac arrest

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