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Statistical thermodynamics through computer simulation to characterize phospholipid interactions in membranes

  • Mihaly Mezei
  • , Pál Jedlovszky

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

11 Scopus citations

Abstract

This chapter describes the major issues that are involved in the statistical thermodynamics of phospholipid membranes at the atomic level. The ingredients going into models of lipid bilayers are summarized: force fields, representation of long-range interactions, and boundary conditions. Next, the choice of thermodynamic ensembles, and the two main options for the generation of a representative sample of configurations: molecular dynamics and Monte Carlo are discussed. The final issue that is dealt with describes the various ways the generated ensembles can be analyzed.

Original languageEnglish
Title of host publicationMethods in Membrane Lipids
EditorsAlex M. Dopico
Pages127-144
Number of pages18
DOIs
StatePublished - 30 Aug 2007

Publication series

NameMethods in Molecular Biology
Volume400
ISSN (Print)1064-3745

Keywords

  • Ewald sum
  • Force field
  • Free-energy profile
  • Molecular dynamics
  • Monte Carlo
  • Voronoi tesselation

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