TY - GEN
T1 - Statistical mechanics of proteins in the random coil state
AU - Bayrak, Cigdem Sevim
AU - Erman, Burak
PY - 2012
Y1 - 2012
N2 - Denatured proteins are mostly partially folded and compact proteins. A statistical analysis on thermodynamic properties is presented to describe and characterize denatured proteins. Conformational free energy, energy, entropy and heat capacity expressions are derived using the Rotational Isomeric States model of polymer theory. The state space and the probabilities of each state are comprised from a coil database. Properties for the denatured state are obtained for a sample set of proteins taken from the Protein Data Bank. Thermodynamic expressions of denatured state are derived.
AB - Denatured proteins are mostly partially folded and compact proteins. A statistical analysis on thermodynamic properties is presented to describe and characterize denatured proteins. Conformational free energy, energy, entropy and heat capacity expressions are derived using the Rotational Isomeric States model of polymer theory. The state space and the probabilities of each state are comprised from a coil database. Properties for the denatured state are obtained for a sample set of proteins taken from the Protein Data Bank. Thermodynamic expressions of denatured state are derived.
KW - Denatured state
KW - Random coil
KW - Rotational isomeric state
UR - https://www.scopus.com/pages/publications/84861996003
M3 - Conference contribution
AN - SCOPUS:84861996003
SN - 9789898425904
T3 - BIOINFORMATICS 2012 - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms
SP - 220
EP - 225
BT - BIOINFORMATICS 2012 - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms
T2 - International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2012
Y2 - 1 February 2012 through 4 February 2012
ER -