Statistical considerations in the evaluation of potential contributions of individual neurobiological differences to cognitive performance. Commentary on Lazic (2010) "Relating hippocampal neurogenesis to behavior: The dangers of ignoring confounding variables"

Jul Lea Shamy; Mark G. Baxter

doi:10.1016/j.neurobiolaging.2010.06.024

Statistical considerations in the evaluation of potential contributions of individual neurobiological differences to cognitive performance. Commentary on Lazic (2010) "Relating hippocampal neurogenesis to behavior: The dangers of ignoring confounding variables"

Jul Lea Shamy, Mark G. Baxter

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

Evaluating the contribution of neurobiological individual differences to cognitive function is critical in order to understand the normal process of learning and memory, to identify the effects of aging and disease states, and to develop targets for therapeutics. The aging model is commonly used for such research as the variability in the aging process provides a naturalistic setting in which to evaluate neurobiological differences in both cognitively impaired and cognitively intact aged individuals. In this commentary we explore Lazic's discussion (2010) about the significance of confounding variables to the interpretation of this research and the effect of common statistical main effects on correlational analyses.

Original language	English
Pages (from-to)	2176-2178
Number of pages	3
Journal	Neurobiology of Aging
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/j.neurobiolaging.2010.06.024
State	Published - Dec 2010

Keywords

Aging
Correlation
Learning
Memory
Neurogenesis
Regression

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Shamy, J. L., & Baxter, M. G. (2010). Statistical considerations in the evaluation of potential contributions of individual neurobiological differences to cognitive performance. Commentary on Lazic (2010) "Relating hippocampal neurogenesis to behavior: The dangers of ignoring confounding variables". Neurobiology of Aging, 31(12), 2176-2178. https://doi.org/10.1016/j.neurobiolaging.2010.06.024

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abstract = "Evaluating the contribution of neurobiological individual differences to cognitive function is critical in order to understand the normal process of learning and memory, to identify the effects of aging and disease states, and to develop targets for therapeutics. The aging model is commonly used for such research as the variability in the aging process provides a naturalistic setting in which to evaluate neurobiological differences in both cognitively impaired and cognitively intact aged individuals. In this commentary we explore Lazic's discussion (2010) about the significance of confounding variables to the interpretation of this research and the effect of common statistical main effects on correlational analyses.",

keywords = "Aging, Correlation, Learning, Memory, Neurogenesis, Regression",

author = "Shamy, {Jul Lea} and Baxter, {Mark G.}",

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Shamy, JL & Baxter, MG 2010, 'Statistical considerations in the evaluation of potential contributions of individual neurobiological differences to cognitive performance. Commentary on Lazic (2010) "Relating hippocampal neurogenesis to behavior: The dangers of ignoring confounding variables"', Neurobiology of Aging, vol. 31, no. 12, pp. 2176-2178. https://doi.org/10.1016/j.neurobiolaging.2010.06.024

Statistical considerations in the evaluation of potential contributions of individual neurobiological differences to cognitive performance. Commentary on Lazic (2010) "Relating hippocampal neurogenesis to behavior: The dangers of ignoring confounding variables". / Shamy, Jul Lea; Baxter, Mark G.
In: Neurobiology of Aging, Vol. 31, No. 12, 12.2010, p. 2176-2178.

Research output: Contribution to journal › Comment/debate

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T1 - Statistical considerations in the evaluation of potential contributions of individual neurobiological differences to cognitive performance. Commentary on Lazic (2010) "Relating hippocampal neurogenesis to behavior

T2 - The dangers of ignoring confounding variables"

AU - Shamy, Jul Lea

AU - Baxter, Mark G.

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AB - Evaluating the contribution of neurobiological individual differences to cognitive function is critical in order to understand the normal process of learning and memory, to identify the effects of aging and disease states, and to develop targets for therapeutics. The aging model is commonly used for such research as the variability in the aging process provides a naturalistic setting in which to evaluate neurobiological differences in both cognitively impaired and cognitively intact aged individuals. In this commentary we explore Lazic's discussion (2010) about the significance of confounding variables to the interpretation of this research and the effect of common statistical main effects on correlational analyses.

KW - Aging

KW - Correlation

KW - Learning

KW - Memory

KW - Neurogenesis

KW - Regression

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DO - 10.1016/j.neurobiolaging.2010.06.024

M3 - Comment/debate

C2 - 20832145

AN - SCOPUS:78650176775

SN - 0197-4580

VL - 31

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JO - Neurobiology of Aging

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Shamy JL, Baxter MG. Statistical considerations in the evaluation of potential contributions of individual neurobiological differences to cognitive performance. Commentary on Lazic (2010) "Relating hippocampal neurogenesis to behavior: The dangers of ignoring confounding variables". Neurobiology of Aging. 2010 Dec;31(12):2176-2178. doi: 10.1016/j.neurobiolaging.2010.06.024