TY - JOUR
T1 - Starting points for a developmental genetics of nerve patterns
AU - Hunt, R. Kevin
AU - Tompkins, Robert
AU - Reinschmidt, Dana
AU - Bodenstein, Lawrence
AU - Murphey, Rodney K.
N1 - Funding Information:
We thank C. Ide and B. Kosofsky for help during the early stages of this manuscript; Tim Baker, Diana Ross, Jennifer Forrence, Kathy Feiock and Kathy Heim for excellent technical assistance; Cynthia Kaye and Fran Baldwin for the illustrations and Barb Eller for preparation of the manuscript. This work was supported by grants from the National Science Foundation (BMS-75-18998; PCM-77-26987; BNS-80-22451; and PCM-79-03827) and computing funds from the Office of the Dean, Johns Hopkins University. Dr. Hunt is a fellow of the Alfred P. Sloan Foundation. Development of the tetraploid line was aided by timely support from a Biomedical Research Support Grant to Tulane University.
PY - 1982
Y1 - 1982
N2 - SYNOPSIS. The genie control of the development of neural morphology and specific neural connections is little known, primarily because of a paucity of neurological mutants in animal models suitable for experimental manipulation. However, by using cell markers-such as tetraploidy, a large cell marker whose development is described here-the development of single retinal cells in tetraploid embryos, the growth of marked polyclones in chimeric eyes, and the central connections of various chimeric eyes have been analyzed to identify the strategies used in molding eye morphology and establishing precise central connections. Theoretical models and computer simulations were used to draw inferences about the information used to accomplish the identified strategies. This analysis resulted in predictions about the sorts of mutant genes which might be found to affect neural ontogeny.
AB - SYNOPSIS. The genie control of the development of neural morphology and specific neural connections is little known, primarily because of a paucity of neurological mutants in animal models suitable for experimental manipulation. However, by using cell markers-such as tetraploidy, a large cell marker whose development is described here-the development of single retinal cells in tetraploid embryos, the growth of marked polyclones in chimeric eyes, and the central connections of various chimeric eyes have been analyzed to identify the strategies used in molding eye morphology and establishing precise central connections. Theoretical models and computer simulations were used to draw inferences about the information used to accomplish the identified strategies. This analysis resulted in predictions about the sorts of mutant genes which might be found to affect neural ontogeny.
UR - https://www.scopus.com/pages/publications/77957213534
U2 - 10.1093/icb/22.1.185
DO - 10.1093/icb/22.1.185
M3 - Article
AN - SCOPUS:77957213534
SN - 1540-7063
VL - 22
SP - 185
EP - 207
JO - Integrative and Comparative Biology
JF - Integrative and Comparative Biology
IS - 1
ER -