Standardizing Scoring Conventions for Crohn's Disease Endoscopy: An International RAND/UCLA Appropriateness Study

Reena Khanna, Christopher Ma, Malcolm Hogan, Guangyong Zou, Talat Bessissow, Brian Bressler, Jean Frédéric Colombel, Silvio Danese, Marco Daperno, James E. East, Lawrence Hookey, Edward V. Loftus, John W.D. McDonald, Remo Panaccione, Laurent Peyrin-Biroulet, Matt Rutter, Bruce E. Sands, Séverine Vermeire, Julie Rémillard, Stefanie C. McFarlaneWilliam J. Sandborn, Geert R. D'Haens, Brian G. Feagan, Vipul Jairath

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background and Aims: Endoscopic assessment of disease activity is integral for evaluating treatment response in patients with Crohn's disease (CD). We aimed to define appropriate items for evaluating endoscopic activity and conventions for consistent endoscopic scoring rules in CD. Methods: A 2-round modified RAND/University of California at Los Angeles Appropriateness Method study was conducted. A panel of 15 gastroenterologists used a 9-point Likert scale to rate the appropriateness of statements pertaining to the Simple Endoscopic Score for CD, Crohn's Disease Endoscopic Index of Severity, and additional items relevant to endoscopy scoring in CD. Each statement was voted as appropriate, uncertain, or inappropriate based on the median panel rating and presence of disagreement. Results: Panelists voted that it is appropriate for all ulcers to contribute to endoscopic scoring in CD, including aphthous ulcers, ulcerations at a surgical anastomosis, and anal canal ulcers (scored in the rectum). Endoscopic healing should reflect an absence of ulcers. Narrowing should be defined as a clear decrease in luminal diameter; stenosis should be defined by an impassable narrowing, and if occurring at the junction of 2 segments, scored in the distal segment. Scarring and inflammatory polyps were considered inappropriate for including in the affected area score. The optimal method for defining ulcer depth remains uncertain. Conclusions: We outlined scoring conventions for the Simple Endoscopic Score for CD and Crohn's Disease Endoscopic Index of Severity, noting that both scores have limitations. Therefore, we identified priorities for future research and steps for developing and validating a more representative endoscopic index in CD.

Original languageEnglish
Pages (from-to)2938-2950.e6
JournalClinical Gastroenterology and Hepatology
Volume21
Issue number11
DOIs
StatePublished - Oct 2023

Keywords

  • Clinical Trials
  • Crohn's Disease
  • Endoscopy
  • Index
  • Outcomes

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