Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action

Jin Xu; Ming Xu; Taylor Brown; Grace C. Rossi; Yasmin L. Hurd; Charles E. Inturrisi; Gavril W. Pasternak; Ying Xian Pan

doi:10.1074/jbc.M113.458687

Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action

Jin Xu, Ming Xu, Taylor Brown, Grace C. Rossi, Yasmin L. Hurd, Charles E. Inturrisi, Gavril W. Pasternak, Ying Xian Pan

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Background: The μ-opioid receptor gene undergoes extensive alternative splicing. Results: The single transmembrane (TM) splice variants function as a chaperone to stabilize 7-TM MOR-1, enhancing morphine analgesia. Conclusion: Single TM variants play an important role in expression and function of 7-TM MOR-1. Significance: The function of truncated variants is significant for understanding the regulation ofμ-opioid receptors or other GPCR families.

Original language	English
Pages (from-to)	21211-21227
Number of pages	17
Journal	Journal of Biological Chemistry
Volume	288
Issue number	29
DOIs	https://doi.org/10.1074/jbc.M113.458687
State	Published - 19 Jul 2013

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title = "Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action",

abstract = "Background: The μ-opioid receptor gene undergoes extensive alternative splicing. Results: The single transmembrane (TM) splice variants function as a chaperone to stabilize 7-TM MOR-1, enhancing morphine analgesia. Conclusion: Single TM variants play an important role in expression and function of 7-TM MOR-1. Significance: The function of truncated variants is significant for understanding the regulation ofμ-opioid receptors or other GPCR families.",

author = "Jin Xu and Ming Xu and Taylor Brown and Rossi, {Grace C.} and Hurd, {Yasmin L.} and Inturrisi, {Charles E.} and Pasternak, {Gavril W.} and Pan, {Ying Xian}",

year = "2013",

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AU - Xu, Jin

AU - Xu, Ming

AU - Brown, Taylor

AU - Rossi, Grace C.

AU - Hurd, Yasmin L.

AU - Inturrisi, Charles E.

AU - Pasternak, Gavril W.

AU - Pan, Ying Xian

PY - 2013/7/19

Y1 - 2013/7/19

N2 - Background: The μ-opioid receptor gene undergoes extensive alternative splicing. Results: The single transmembrane (TM) splice variants function as a chaperone to stabilize 7-TM MOR-1, enhancing morphine analgesia. Conclusion: Single TM variants play an important role in expression and function of 7-TM MOR-1. Significance: The function of truncated variants is significant for understanding the regulation ofμ-opioid receptors or other GPCR families.

AB - Background: The μ-opioid receptor gene undergoes extensive alternative splicing. Results: The single transmembrane (TM) splice variants function as a chaperone to stabilize 7-TM MOR-1, enhancing morphine analgesia. Conclusion: Single TM variants play an important role in expression and function of 7-TM MOR-1. Significance: The function of truncated variants is significant for understanding the regulation ofμ-opioid receptors or other GPCR families.

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IS - 29

ER -

Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action

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