@article{5accf1f378d74f96bdef8c8165529a98,
title = "Stability in BMI over time is associated with a better cognitive trajectory in older adults",
abstract = "Objective: Evidence on simultaneous changes in body mass index (BMI) and cognitive decline, which better reflect the natural course of both health phenomena, is limited. Methods: We capitalized on longitudinal data from 15,977 initially non-demented elderly from the Alzheimer's Disease Centers followed for 5 years on average. Changes in BMI were defined as (1) last minus first BMI, (2) mean of all follow-up BMIs minus first BMI, and (3) standard deviation of BMI change from baseline and all follow-up visits (representing variability). Results: Participants with significant changes in BMI (increase or decrease of ≥5%), or who had greater variability in BMI, had faster cognitive decline. This pattern was consistent irrespective of normal (BMI < 25; N = 5747), overweight (25 ≤ BMI < 30; N = 6302), or obese (BMI ≥ 30; N = 3928) BMI at baseline. Conclusions: Stability in BMI predicts better cognitive trajectories suggesting clinical value in tracking BMI change, which is simple to measure, and may point to individuals whose cognition is declining.",
keywords = "Cognitive decline, body mass index, older adults, stability",
author = "Beeri, {Michal Schnaider} and Amir Tirosh and Lin, {Hung Mo} and Sapir Golan and Ethel Boccara and Mary Sano and Zhu, {Carolyn W.}",
note = "Funding Information: National Institute on Aging (NIA) P50 AG005138 AG016976 P30 AG066514 for Mary Sano, and R01 AG034087, R01 AG053446, R01 AG051545, R01 AG061093, and AG043878 for Michal Schnaider Beeri. Mary Sano and Carolyn W. Zhu also are supported by the Department of Veterans Affairs, Veterans Health Administration. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs. Funding Information: National Institute on Aging (NIA) P50 AG005138 AG016976 P30 AG066514 for Mary Sano, and R01 AG034087, R01 AG053446, R01 AG051545, R01 AG061093, and AG043878 for Michal Schnaider Beeri. Mary Sano and Carolyn W. Zhu also are supported by the Department of Veterans Affairs, Veterans Health Administration. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs. Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",
year = "2022",
month = nov,
doi = "10.1002/alz.12525",
language = "English",
volume = "18",
pages = "2131--2139",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "John Wiley & Sons Inc.",
number = "11",
}