Stability and plasticity of wild-type and Pax5-deficient precursor B cells

Antonius G. Rolink; Christoph Schaniel; Fritz Melchers

doi:10.1034/j.1600-065X.2002.18708.x

Stability and plasticity of wild-type and Pax5-deficient precursor B cells

Antonius G. Rolink, Christoph Schaniel, Fritz Melchers

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

In Pax5-deficient mice, B cell development is blocked at the pre-BI cell stage. Like wild-type, Pax5^-/- pre-BI cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild-type in vitro-grown counterparts, Pax5^-/- pre-BI cells possess an extraordinary developmental plasticity showing hematopoietic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax5^-/- pre-BI cells.

Original language	English
Pages (from-to)	87-95
Number of pages	9
Journal	Immunological Reviews
Volume	187
DOIs	https://doi.org/10.1034/j.1600-065X.2002.18708.x
State	Published - Sep 2002
Externally published	Yes

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title = "Stability and plasticity of wild-type and Pax5-deficient precursor B cells",

abstract = "In Pax5-deficient mice, B cell development is blocked at the pre-BI cell stage. Like wild-type, Pax5-/- pre-BI cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild-type in vitro-grown counterparts, Pax5-/- pre-BI cells possess an extraordinary developmental plasticity showing hematopoietic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax5-/- pre-BI cells.",

author = "Rolink, {Antonius G.} and Christoph Schaniel and Fritz Melchers",

year = "2002",

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doi = "10.1034/j.1600-065X.2002.18708.x",

language = "English",

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journal = "Immunological Reviews",

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AU - Rolink, Antonius G.

AU - Schaniel, Christoph

AU - Melchers, Fritz

PY - 2002/9

Y1 - 2002/9

N2 - In Pax5-deficient mice, B cell development is blocked at the pre-BI cell stage. Like wild-type, Pax5-/- pre-BI cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild-type in vitro-grown counterparts, Pax5-/- pre-BI cells possess an extraordinary developmental plasticity showing hematopoietic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax5-/- pre-BI cells.

AB - In Pax5-deficient mice, B cell development is blocked at the pre-BI cell stage. Like wild-type, Pax5-/- pre-BI cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild-type in vitro-grown counterparts, Pax5-/- pre-BI cells possess an extraordinary developmental plasticity showing hematopoietic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax5-/- pre-BI cells.

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U2 - 10.1034/j.1600-065X.2002.18708.x

DO - 10.1034/j.1600-065X.2002.18708.x

M3 - Review article

C2 - 12366685

AN - SCOPUS:0036749736

SN - 0105-2896

VL - 187

SP - 87

EP - 95

JO - Immunological Reviews

JF - Immunological Reviews

ER -

Stability and plasticity of wild-type and Pax5-deficient precursor B cells

Abstract

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