Src family protein tyrosine kinase regulates the basolateral K channel in the distal convoluted tubule (DCT) by phosphorylation of KCNJ10 protein

Chengbiao Zhang; Lijun Wang; Sherin Thomas; Kemeng Wang; Dao Hong Lin; Jesse Rinehart; Wen Hui Wang

doi:10.1074/jbc.M113.478453

Src family protein tyrosine kinase regulates the basolateral K channel in the distal convoluted tubule (DCT) by phosphorylation of KCNJ10 protein

Chengbiao Zhang
, Lijun Wang
, Sherin Thomas
, Kemeng Wang
, Dao Hong Lin
, Jesse Rinehart
, Wen Hui Wang

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Background: KCNJ10 is a key component of the basolateral K channels in DCT. Results: SFK phosphorylates KCNJ10 at Tyr9, and inhibition of SFK decreases basolateral K channel activity in DCT. Conclusion: SFK stimulates the basolateral K channels in DCT by phosphorylating KCNJ10. Significance: Tyrosine phosphorylation of KCNJ10 plays a role in regulating membrane transport in DCT.

Original language	English
Pages (from-to)	26135-26146
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.478453
State	Published - 6 Sep 2013
Externally published	Yes

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title = "Src family protein tyrosine kinase regulates the basolateral K channel in the distal convoluted tubule (DCT) by phosphorylation of KCNJ10 protein",

abstract = "Background: KCNJ10 is a key component of the basolateral K channels in DCT. Results: SFK phosphorylates KCNJ10 at Tyr9, and inhibition of SFK decreases basolateral K channel activity in DCT. Conclusion: SFK stimulates the basolateral K channels in DCT by phosphorylating KCNJ10. Significance: Tyrosine phosphorylation of KCNJ10 plays a role in regulating membrane transport in DCT.",

author = "Chengbiao Zhang and Lijun Wang and Sherin Thomas and Kemeng Wang and Lin, \{Dao Hong\} and Jesse Rinehart and Wang, \{Wen Hui\}",

year = "2013",

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doi = "10.1074/jbc.M113.478453",

language = "English",

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T1 - Src family protein tyrosine kinase regulates the basolateral K channel in the distal convoluted tubule (DCT) by phosphorylation of KCNJ10 protein

AU - Zhang, Chengbiao

AU - Wang, Lijun

AU - Thomas, Sherin

AU - Wang, Kemeng

AU - Lin, Dao Hong

AU - Rinehart, Jesse

AU - Wang, Wen Hui

PY - 2013/9/6

Y1 - 2013/9/6

N2 - Background: KCNJ10 is a key component of the basolateral K channels in DCT. Results: SFK phosphorylates KCNJ10 at Tyr9, and inhibition of SFK decreases basolateral K channel activity in DCT. Conclusion: SFK stimulates the basolateral K channels in DCT by phosphorylating KCNJ10. Significance: Tyrosine phosphorylation of KCNJ10 plays a role in regulating membrane transport in DCT.

AB - Background: KCNJ10 is a key component of the basolateral K channels in DCT. Results: SFK phosphorylates KCNJ10 at Tyr9, and inhibition of SFK decreases basolateral K channel activity in DCT. Conclusion: SFK stimulates the basolateral K channels in DCT by phosphorylating KCNJ10. Significance: Tyrosine phosphorylation of KCNJ10 plays a role in regulating membrane transport in DCT.

UR - https://www.scopus.com/pages/publications/84883721609

U2 - 10.1074/jbc.M113.478453

DO - 10.1074/jbc.M113.478453

M3 - Article

C2 - 23873931

AN - SCOPUS:84883721609

SN - 0021-9258

VL - 288

SP - 26135

EP - 26146

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 36

ER -

Src family protein tyrosine kinase regulates the basolateral K channel in the distal convoluted tubule (DCT) by phosphorylation of KCNJ10 protein

Abstract

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