Squamous cell carcinoma of the tongue: The prevalence and prognostic roles of p53, Bcl-2, c-erbB-2 and apoptotic rate as related to clinical and pathological characteristics in a retrospective study

Rafael M. Nagler, Hedviga Kerner, Dov Laufer, Shoshana Ben-Eliezer, Ira Minkov, Ofer Ben-Itzhak

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

In the current study, we examined the clinical characteristics and survival probability rates of 116 patients treated for squamous cell carcinoma (SCC) of the tongue. In 55 randomly selected patients these data were correlated with the immunohistological analysis of the tumor and apoptosis-related markers, p53, Bcl-2, c-erbB-2 (Her-2/neu), and to the apoptosis rate assessment by the terminal dUTP nick-end-labeling (TUNEL) method. The overall 5-year survival probability was 55%, which might be the result of the low incidence of smoking and/or alcohol consumption among the patients (21%), the early diagnosis (65% at Stages I-II) and the low histological grades (91% good-moderate). Radiotherapeutic or surgical treatment of the neck did not alter the survival probability achieved by local surgery for Stage I patients, but significantly improved survival for Stage II patients. Independent tumor-related variables which significantly worsened the probability of survival were found. Concomitant non-oral cancer was found to be a poor variable for prognosis prediction. Positive staining of p53, TUNEL (apoptosis rate), c-erbB-2 and Bcl-2 was found in 60, 48, 18 and 15% of the lesions, respectively (P<0.0001). The possible biological significance of these markers in tongue SCC is discussed in relation to the current literature, and an independent role for TUNEL and p53 is suggested.

Original languageEnglish
Pages (from-to)137-150
Number of pages14
JournalCancer Letters
Volume186
Issue number2
DOIs
StatePublished - 5 Dec 2002
Externally publishedYes

Keywords

  • Bcl-2
  • C-erbB-2
  • P53
  • Squamous cell carcinoma
  • Terminal dUTP nick-end-labelling
  • Tongue

Fingerprint

Dive into the research topics of 'Squamous cell carcinoma of the tongue: The prevalence and prognostic roles of p53, Bcl-2, c-erbB-2 and apoptotic rate as related to clinical and pathological characteristics in a retrospective study'. Together they form a unique fingerprint.

Cite this