TY - JOUR
T1 - Sprouty proteins
T2 - Multifaceted negative-feedback regulators of receptor tyrosine kinase signaling
AU - Mason, Jacqueline M.
AU - Morrison, Debra J.
AU - Basson, M. Albert
AU - Licht, Jonathan D.
N1 - Funding Information:
We thank Gail Martin for permission to adapt Figure 1 from Shim et al. and for insightful discussions, and Steve McKnight for sharing unpublished data. We apologize to those colleagues whose contributions we were unable to include owing to limitations on reference citations. Supported by NIH Grants CA59998 and DK62345 (J.D.L.), the Revson Foundation for Biomedical Research (J.M.M.) and the Wellcome Trust (M.A.B.).
PY - 2006/1
Y1 - 2006/1
N2 - Receptor tyrosine kinases (RTKs) control a wide variety of processes in multicellular organisms, including proliferation, differentiation, migration and survival. Their activity is tightly controlled through the coordinated action of both positive and negative regulators that function at multiple levels of the signal transduction cascade, and at different time points within the growth-factor-induced response. When this process goes awry, the outcome can be developmental defects and malignancy. Sprouty (Spry) proteins represent a major class of ligand-inducible inhibitors of RTK-dependent signaling pathways. New biochemical and genetic evidence indicates specific roles of the Spry genes in development and multiple modes of action of the Spry proteins in regulation of the RTK-induced response.
AB - Receptor tyrosine kinases (RTKs) control a wide variety of processes in multicellular organisms, including proliferation, differentiation, migration and survival. Their activity is tightly controlled through the coordinated action of both positive and negative regulators that function at multiple levels of the signal transduction cascade, and at different time points within the growth-factor-induced response. When this process goes awry, the outcome can be developmental defects and malignancy. Sprouty (Spry) proteins represent a major class of ligand-inducible inhibitors of RTK-dependent signaling pathways. New biochemical and genetic evidence indicates specific roles of the Spry genes in development and multiple modes of action of the Spry proteins in regulation of the RTK-induced response.
UR - http://www.scopus.com/inward/record.url?scp=30444441147&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2005.11.004
DO - 10.1016/j.tcb.2005.11.004
M3 - Review article
C2 - 16337795
AN - SCOPUS:30444441147
SN - 0962-8924
VL - 16
SP - 45
EP - 54
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 1
ER -