Spontaneous versus mechanical ventilation during video-assisted thoracoscopic surgery for spontaneous pneumothorax: A randomized trial

International Tubeless-Video-Assisted Thoracoscopic Surgery Collaboration

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: Spontaneous ventilation video-assisted thoracic surgery (SV-VATS) is reported to have superior or equal efficacy on postoperative recovery to mechanical ventilation VATS (MV-VATS). However, perioperative safety of the SV-VATS blebectomy is not entirely demonstrated. Methods: We performed a noninferiority, randomized controlled trial (No. NCT03016858) for primary spontaneous pneumothorax patients aged 16 to 50 years undergoing a SV-VATS and the MV-VATS procedure. The trial was conducted at 10 centers in China from April 2017 to January 2019. The primary outcome was the comparison of intra- and postoperative complications between SV-VATS and MV-VATS procedures. Secondary outcomes included total analgesia dose, change of vital sign during surgery, procedural duration, recovery time, postoperative visual analog pain scores, and hospitalization length. Results: In this study, 335 patients were included. There was no significant difference between the SV-VATS group and the MV-VATS group in the intra- and postoperative complication rates (17.90% vs 22.09%; relative risk, 0.81; 95% confidence interval, 0.52-1.26; P =.346). The SV-VATS group was associated with significantly decreased total dose of intraoperative opioid agents; that is, sufentanil (11.37 μg vs 20.92 μg; P <.001) and remifentanil (269.78 μg vs 404.96 μg; P <.001). The SV-VATS procedure was also associated with shorter extubation time (12.28 minutes vs 17.30 minutes; P <.001), postanesthesia care unit recovery time (25.43 minutes vs 30.67 minutes; P =.02) and food intake time (346.07 minute vs 404.02 minutes; P =.002). Moreover, the SV-VATS procedure deceased the anesthesia cost compared with the MV-VATS ($297.81 vs $399.81; P <.001). Conclusions: SV-VATS was shown to be noninferior to MV-VATS in term of complication rate and in selected patients undergoing blebectomy for primary spontaneous pneumothorax.

Original languageEnglish
Pages (from-to)1702-1714.e7
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number5
StatePublished - May 2022


  • mechanical ventilation
  • opioid anesthesia
  • randomized controlled clinical trial
  • spontaneous ventilation
  • video-assisted thoracoscopic surgery


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