Spontaneous expression of Endogenous type C RNA virus by BALB/c splenic B lymphocytes in continuous culture

E. Premkumar-Reddy, Paul J. Price, Conrad J. Heilman, Padman S. Sarma

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

B-lymphocyte cultures were established from spleens of BALB/c, C57B1/6, NIH Swiss, and SWR mice of various age groups. Spontaneous, consistent, and thus predictable release of a B-tropic mouse endogenous virus occurred from the very first passage in cultured lymphocytes derived from BALB/c mice 6 months old or older but not from similar lymphocytes derived from BALB/c mice of 1.5 or 3 months of age. C57Bl/6, NIH Swiss, and SWR mice belonging to various age groups ranging between 1.5 and 18 months failed to exhibit such a spontaneous release of viral particles. We conclude that in BALB/c splenic B lymphocytes a breakdown of cellular control mechanisms occurs in older animals leading to viral production while such a phenomenon is absent in C57Bl/6, NIH Swiss, and SWR mice.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalVirology
Volume84
Issue number2
DOIs
StatePublished - Feb 1978
Externally publishedYes

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