TY - JOUR
T1 - Spontaneous expression of Endogenous type C RNA virus by BALB/c splenic B lymphocytes in continuous culture
AU - Premkumar-Reddy, E.
AU - Price, Paul J.
AU - Heilman, Conrad J.
AU - Sarma, Padman S.
N1 - Funding Information:
The work presented in this paper was supported by NIH Contract No. NOl-CP-43254 of the Virus Cancer Program, National Cancer Institute, Bethesda, Maryland 20014. We are grateful to Drs. Robert Peters and Wallace Rowe for the giR of some of the animals used in this study and to Drs. Janet Hartley and Michael Potter for useful discussions.
PY - 1978/2
Y1 - 1978/2
N2 - B-lymphocyte cultures were established from spleens of BALB/c, C57B1/6, NIH Swiss, and SWR mice of various age groups. Spontaneous, consistent, and thus predictable release of a B-tropic mouse endogenous virus occurred from the very first passage in cultured lymphocytes derived from BALB/c mice 6 months old or older but not from similar lymphocytes derived from BALB/c mice of 1.5 or 3 months of age. C57Bl/6, NIH Swiss, and SWR mice belonging to various age groups ranging between 1.5 and 18 months failed to exhibit such a spontaneous release of viral particles. We conclude that in BALB/c splenic B lymphocytes a breakdown of cellular control mechanisms occurs in older animals leading to viral production while such a phenomenon is absent in C57Bl/6, NIH Swiss, and SWR mice.
AB - B-lymphocyte cultures were established from spleens of BALB/c, C57B1/6, NIH Swiss, and SWR mice of various age groups. Spontaneous, consistent, and thus predictable release of a B-tropic mouse endogenous virus occurred from the very first passage in cultured lymphocytes derived from BALB/c mice 6 months old or older but not from similar lymphocytes derived from BALB/c mice of 1.5 or 3 months of age. C57Bl/6, NIH Swiss, and SWR mice belonging to various age groups ranging between 1.5 and 18 months failed to exhibit such a spontaneous release of viral particles. We conclude that in BALB/c splenic B lymphocytes a breakdown of cellular control mechanisms occurs in older animals leading to viral production while such a phenomenon is absent in C57Bl/6, NIH Swiss, and SWR mice.
UR - http://www.scopus.com/inward/record.url?scp=0017875212&partnerID=8YFLogxK
U2 - 10.1016/0042-6822(78)90253-2
DO - 10.1016/0042-6822(78)90253-2
M3 - Article
C2 - 74896
AN - SCOPUS:0017875212
SN - 0042-6822
VL - 84
SP - 341
EP - 347
JO - Virology
JF - Virology
IS - 2
ER -