Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women

Siiri E. Iismaa, Stephanie Hesselson, Lucy McGrath-Cadell, David W. Muller, Diane Fatkin, Eleni Giannoulatou, Jason Kovacic, Robert M. Graham

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

The burden of cardiovascular disease in women is being increasingly appreciated. Nevertheless, both clinicians and the general public are largely unaware that cardiovascular disease is the leading cause of death worldwide in women in all countries and that outcomes after a heart attack are worse for women than men. Of note, certain types of cardiovascular disease have a predilection for women, including spontaneous coronary artery dissection (SCAD) and fibromuscular dysplasia (FMD). Although uncommon, SCAD is being increasingly recognised as the cause of an acute coronary syndrome (ACS) and can recur. It is a potentially fatal, under-diagnosed condition that affects relatively young women, who often have few traditional risk factors, and is the commonest cause of a myocardial infarction associated with pregnancy. In contrast, FMD often remains silent but when manifested can also cause major sequelae, including renal infarction, stroke, cervical artery dissection and gut infarction. Here we provide an update on the diagnosis, aetiology and management of these important disorders that overwhelmingly affect women.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalHeart Lung and Circulation
Volume30
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • Fibromuscular dysplasia
  • Heart disease
  • Spontaneous coronary artery dissection
  • Women

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