Spondylodiscitis due to Cutibacterium acnes following lumbosacral intradiscal biologic therapy: A case report

Nicholas R. Beatty, Cole Lutz, Kwadwo Boachie-Adjei, Teresita A. Leynes, Christopher Lutz, Gregory Lutz

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A 40-year-old woman with a history of chronic low back pain underwent a fluoroscopically guided intradiscal platelet-rich plasma injection (PRP) at the L5-S1 level. She subsequently developed progressive low back pain, night sweats and decreased ability to ambulate. Laboratory work-up revealed elevated acute phase reactants and imaging revealed L5-S1 intervertebral disc and vertebral end-plate abnormalities highly suggestive of spondylodiscitis. Computed tomography-guided aspiration and biopsy cultures grew Cutibacterium acnes and the patient was subsequently treated with intravenous antibiotics without surgical management. To the best of our knowledge, this is the first published case of lumbar spondylodiscitis following an intradiscal PRP injection, and brings to the forefront several clinically relevant issues including the antimicrobial effects of PRP, the role of C. acnes in spine infections and the ideal treatment protocol for intradiscal biologics in order to minimize morbidity and optimize functional outcomes.

Original languageEnglish
Pages (from-to)823-829
Number of pages7
JournalRegenerative Medicine
Issue number9
StatePublished - 2019


  • Cutibacterium acnes
  • degenerative disc disease
  • discitis
  • intradiscal biologic therapy
  • intradiscal platelet-rich plasma
  • orthobiologics
  • regenerative medicine
  • spine care
  • spondylodiscitis


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