Splice or Die: When MYC Is Driving, Transcription Needs NUAK1 to Avoid Fatal Pileups

Robert P. Fisher

doi:10.1016/j.molcel.2020.02.025

Splice or Die: When MYC Is Driving, Transcription Needs NUAK1 to Avoid Fatal Pileups

Robert P. Fisher

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

In this issue of Molecular Cell, Cossa et al. (2020) uncover the basis for a dependency of tumor cells with deregulated MYC on the kinase NUAK1, which acts through PP1 and PNUTS to ensure that splicing keeps up with MYC-driven transcription.

Original language	English
Pages (from-to)	1157-1158
Number of pages	2
Journal	Molecular Cell
Volume	77
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2020.02.025
State	Published - 19 Mar 2020

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title = "Splice or Die: When MYC Is Driving, Transcription Needs NUAK1 to Avoid Fatal Pileups",

abstract = "In this issue of Molecular Cell, Cossa et al. (2020) uncover the basis for a dependency of tumor cells with deregulated MYC on the kinase NUAK1, which acts through PP1 and PNUTS to ensure that splicing keeps up with MYC-driven transcription.",

author = "Fisher, {Robert P.}",

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year = "2020",

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doi = "10.1016/j.molcel.2020.02.025",

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AU - Fisher, Robert P.

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N2 - In this issue of Molecular Cell, Cossa et al. (2020) uncover the basis for a dependency of tumor cells with deregulated MYC on the kinase NUAK1, which acts through PP1 and PNUTS to ensure that splicing keeps up with MYC-driven transcription.

AB - In this issue of Molecular Cell, Cossa et al. (2020) uncover the basis for a dependency of tumor cells with deregulated MYC on the kinase NUAK1, which acts through PP1 and PNUTS to ensure that splicing keeps up with MYC-driven transcription.

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DO - 10.1016/j.molcel.2020.02.025

M3 - Comment/debate

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SN - 1097-2765

VL - 77

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EP - 1158

JO - Molecular Cell

JF - Molecular Cell

IS - 6

ER -

Splice or Die: When MYC Is Driving, Transcription Needs NUAK1 to Avoid Fatal Pileups

Abstract

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