TY - JOUR
T1 - Splanchnic Vein Thrombosis in Myeloproliferative Neoplasms
T2 - Treatment Considerations and Unmet Needs
AU - Liu, Angela
AU - Naymagon, Leonard
AU - Tremblay, Douglas
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2023/1
Y1 - 2023/1
N2 - Patients who develop splanchnic vein thrombosis (SVT) in the setting of a myeloproliferative neoplasm (MPN) are at risk for complications including portal hypertension, bleeding, thrombosis, and death. Prompt multidisciplinary treatment is thus necessary to prevent long-term sequelae. However, optimal management strategies are not well established due to a paucity of data. In this review, we very briefly discuss the epidemiology, pathophysiology, and prognosis of MPN-SVT and then more comprehensively explore treatment considerations of MPN-SVT, including anticoagulation, endovascular/surgical intervention, and cytoreductive therapy. We will also highlight current gaps in our knowledge of MPN-SVT and conclude by suggesting future directions to optimize the treatment of MPN-SVT and improve outcomes.
AB - Patients who develop splanchnic vein thrombosis (SVT) in the setting of a myeloproliferative neoplasm (MPN) are at risk for complications including portal hypertension, bleeding, thrombosis, and death. Prompt multidisciplinary treatment is thus necessary to prevent long-term sequelae. However, optimal management strategies are not well established due to a paucity of data. In this review, we very briefly discuss the epidemiology, pathophysiology, and prognosis of MPN-SVT and then more comprehensively explore treatment considerations of MPN-SVT, including anticoagulation, endovascular/surgical intervention, and cytoreductive therapy. We will also highlight current gaps in our knowledge of MPN-SVT and conclude by suggesting future directions to optimize the treatment of MPN-SVT and improve outcomes.
KW - essential thrombocythemia
KW - myelofibrosis
KW - myeloproliferative
KW - polycythemia vera
KW - splanchnic vein
KW - thrombosis
UR - http://www.scopus.com/inward/record.url?scp=85145559123&partnerID=8YFLogxK
U2 - 10.3390/cancers15010011
DO - 10.3390/cancers15010011
M3 - Review article
AN - SCOPUS:85145559123
SN - 2072-6694
VL - 15
JO - Cancers
JF - Cancers
IS - 1
M1 - 11
ER -