Splanchnic vein thrombosis (SVT) in the setting of myeloproliferative neoplasm (MPN) is a unique clinical entity that requires close interdisciplinary coordination for proper diagnosis and management. The pathobiology of MPN-SVT is not fully understood, but recent developments have revealed the central role of endothelial cells. In this multidisciplinary review, we summarize the epidemiology of MPN-SVT and then critically evaluate the pathogenic features of this complication, with a focus on endothelial cell biology. We then discuss diagnostic considerations, including imaging modalities and MPN-specific investigations. Finally, we critically review the evidence supporting clinical management of MPN-SVT, including anticoagulation, interventional radiology procedures, MPN-related therapies, and liver transplantation. We conclude that further studies are needed to improve our understanding of MPN-SVT and the outcomes of patients with this debilitating complication.

Original languageEnglish
Pages (from-to)8-16
Number of pages9
JournalThrombosis Research
StatePublished - Oct 2022


  • Essential thrombocythemia
  • Myelofibrosis
  • Myeloproliferative
  • Polycythemia vera
  • Splanchnic vein
  • Thrombosis


Dive into the research topics of 'Splanchnic vein thrombosis associated with myeloproliferative neoplasms'. Together they form a unique fingerprint.

Cite this