Spiking fevers with clozapine treatment

Fabien Trémeau, Scott C. Clark, David Printz, Lawrence S. Kegeles, Dolores Malaspina

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Clozapine often causes low-grade fever and less frequently spiking fever. We describe three cases of spiking fever that occurred in the first 3 weeks of clozapine therapy. A new set of side effects of clozapine is identified, which includes spiking fever, respiratory and gastrointestinal symptoms, and neutrophilia. Possible mechanisms are discussed.

Original languageEnglish
Pages (from-to)168-170
Number of pages3
JournalClinical Neuropharmacology
Issue number2
StatePublished - 1997
Externally publishedYes


  • Clozapine
  • Dopamine
  • Neutrophilia
  • Side effect
  • Spiking fever


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