Sphenoid cranial base defects in siblings presenting with cerebrospinal fluid leak

Joseph M. Bernstein, J. Thomas Roland, Mark S. Persky

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Two sisters presented to our medical center with nontraumatic cerebrospinal fluid (CSF) fistulas from left sphenoid sinocranial junction defects. One sister had recurrent meningitis over a 20-year period that prompted a skull base evaluation. Four years later, her younger sister presented with profuse CSF rhinorrhea. Transethmoid sphenoidotomy with sinus obliteration and lumbar-subarachnoid temporary CSF diversion successfully treated one sister, while the other required reoperation and permanent lumbar-peritoneal shunting. In both cases the skull base defect was identically located in the posterolateral left sphenoid sinus. Embryological considerations, evaluation, and management are presented.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalSkull Base Surgery
Volume7
Issue number4
DOIs
StatePublished - 1997
Externally publishedYes

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