TY - CHAP
T1 - Speculation and Deductive Reasoning About Ovarian Epithelial Carcinogenesis and New Horizons
AU - Altchek, Albert
AU - Deligdisch, Liane
AU - Penault-Llorca, Frédŕique
N1 - Publisher Copyright:
© 2004 Elsevier Inc. All rights reserved.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Most ovarian carcinomas develop from surface type epithelium. Approximately90% of these are sporadic in nature and develop from acquired somatic mutations and the remaining 10% result from an inherited tendency with an increased incidence and earlier onset, usually associated with inherited germplasm mutations. This chapter highlights deductive reasoning about ovarian epithelial carcinogenesis and gives insights on new horizons. Deductive reasoning essentially explains cancer formation in inclusion cysts, the role of the stroma, the time period for cancer to develop, the myth of the “evil genius” cancer, the superficial nature of most intraperitoneal metastases, mechanism of multifocal peritoneal carcinomatosis, and a reason for recurrence. Recent advances in research are opening many new horizons and suggest for improved researcher communication, improved ultrasound resolution and serum tumor markers, and chemoprevention.
AB - Most ovarian carcinomas develop from surface type epithelium. Approximately90% of these are sporadic in nature and develop from acquired somatic mutations and the remaining 10% result from an inherited tendency with an increased incidence and earlier onset, usually associated with inherited germplasm mutations. This chapter highlights deductive reasoning about ovarian epithelial carcinogenesis and gives insights on new horizons. Deductive reasoning essentially explains cancer formation in inclusion cysts, the role of the stroma, the time period for cancer to develop, the myth of the “evil genius” cancer, the superficial nature of most intraperitoneal metastases, mechanism of multifocal peritoneal carcinomatosis, and a reason for recurrence. Recent advances in research are opening many new horizons and suggest for improved researcher communication, improved ultrasound resolution and serum tumor markers, and chemoprevention.
UR - http://www.scopus.com/inward/record.url?scp=84902216803&partnerID=8YFLogxK
U2 - 10.1016/B978-012053642-9/50027-2
DO - 10.1016/B978-012053642-9/50027-2
M3 - Chapter
AN - SCOPUS:84902216803
SP - 305
EP - 323
BT - Diagnosis and Management of Ovarian Disorders, Second Edition
PB - Elsevier
ER -