Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

Tao Yang; Xiaohui Wang; Changli Zhang; Xiang Ma; Kun Wang; Yanqing Wang; Jian Luo; Liu Yang; Cheng Yao; Xiaoyong Wang

doi:10.1039/c5cc08898d

Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

Tao Yang
, Xiaohui Wang
, Changli Zhang
, Xiang Ma
, Kun Wang
, Yanqing Wang
, Jian Luo
, Liu Yang
, Cheng Yao
, Xiaoyong Wang

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A dual-functional fluorescent chelator can specifically target and disassemble metal-associated Aβ aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.

Original language	English
Pages (from-to)	2245-2248
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	11
DOIs	https://doi.org/10.1039/c5cc08898d
State	Published - 7 Feb 2016
Externally published	Yes

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title = "Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator",

abstract = "A dual-functional fluorescent chelator can specifically target and disassemble metal-associated Aβ aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.",

author = "Tao Yang and Xiaohui Wang and Changli Zhang and Xiang Ma and Kun Wang and Yanqing Wang and Jian Luo and Liu Yang and Cheng Yao and Xiaoyong Wang",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

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doi = "10.1039/c5cc08898d",

language = "English",

volume = "52",

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TY - JOUR

T1 - Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

AU - Yang, Tao

AU - Wang, Xiaohui

AU - Zhang, Changli

AU - Ma, Xiang

AU - Wang, Kun

AU - Wang, Yanqing

AU - Luo, Jian

AU - Yang, Liu

AU - Yao, Cheng

AU - Wang, Xiaoyong

PY - 2016/2/7

Y1 - 2016/2/7

N2 - A dual-functional fluorescent chelator can specifically target and disassemble metal-associated Aβ aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.

AB - A dual-functional fluorescent chelator can specifically target and disassemble metal-associated Aβ aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.

UR - https://www.scopus.com/pages/publications/84957094381

U2 - 10.1039/c5cc08898d

DO - 10.1039/c5cc08898d

M3 - Article

C2 - 26688576

AN - SCOPUS:84957094381

SN - 1359-7345

VL - 52

SP - 2245

EP - 2248

JO - Chemical Communications

JF - Chemical Communications

IS - 11

ER -

Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

Abstract

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