Specific helper T cell reactivity against autologous erythrocytes implies that self tolerance need not depend on clonal deletion

D. Craig Hooper, Roger B. Taylor

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Using a culture system which supports primary T cell proliferative responses to various antigens we have detected mouse red blood cell (RBC)‐reactive T cells in lymphoid tissues from untreated mice. The release of significant amounts of interleukin 2 (IL2) indicates that T helper (or helper/inducer) cells are activated by stimulation with RBC. Upon restimulation in vitro these cells proliferate specifically against mouse RBC with the kinetics and magnitude characteristic of a secondary response. Since autologous RBC are tolerated in vivo in spite of the presence of such specifically reactive T helper cells, these findings imply that self tolerance, even to certain nonse‐questered antigens, may depend largely on regulatory mechanisms rather than on clonal deletion or inactivation.

Original languageEnglish
Pages (from-to)797-802
Number of pages6
JournalEuropean Journal of Immunology
Volume17
Issue number6
DOIs
StatePublished - 1987
Externally publishedYes

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