Specific Binding of Liposomal Nanoparticles through Inverse Electron-Demand Diels–Alder Click Chemistry

Christian Brand, Pasquale Iacono, Carlos Pérez-Medina, Willem J.M. Mulder, Moritz F. Kircher, Thomas Reiner

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron-demand Diels–Alder reaction. Inspired by recent accomplishments in pre-targeted imaging using tetrazine-trans-cyclooctene click chemistry, we synthesized 89Zr-labeled trans-cyclooctene-functionalized liposomal nanoparticles, which were validated on a tetrazine-appended polydopamine-coated CoCrMo surface. In efforts to ultimately translate this new material to biomedical applications, we compared the ability of 89Zr-TCO–liposomal nanoparticles (89Zr-TCO-LNP) to be immobilized on the tetrazine surface to the control suspensions of non-TCO functionalized 89Zr-liposomal nanoparticles. Ultimately, this platform technology could result in a systemic decrease of the radiotherapeutic dose deposited in non-targeted tissues by specific removal of long-circulating liposomal radiopharmaceuticals from the blood pool.

Original languageEnglish
Pages (from-to)615-619
Number of pages5
Issue number5
StatePublished - Oct 2017


  • CoCrMo alloys
  • Zr
  • click chemistry
  • liposomes
  • tetrazine
  • trans-cyclooctene


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