Specializations for reward-guided decision-making in the primate ventral prefrontal cortex

Elisabeth A. Murray, Peter H. Rudebeck

Research output: Contribution to journalReview articlepeer-review

106 Scopus citations


The estimated values of choices, and therefore decision-making based on those values, are influenced by both the chance that the chosen items or goods can be obtained (availability) and their current worth (desirability) as well as by the ability to link the estimated values to choices (a process sometimes called credit assignment). In primates, the prefrontal cortex (PFC) has been thought to contribute to each of these processes; however, causal relationships between particular subdivisions of the PFC and specific functions have been difficult to establish. Recent lesion-based research studies have defined the roles of two different parts of the primate PFC - the orbitofrontal cortex (OFC) and the ventral lateral frontal cortex (VLFC) - and their subdivisions in evaluating each of these factors and in mediating credit assignment during reward-based decision-making.

Original languageEnglish
Pages (from-to)404-417
Number of pages14
JournalNature Reviews Neuroscience
Issue number7
StatePublished - 1 Jul 2018


Dive into the research topics of 'Specializations for reward-guided decision-making in the primate ventral prefrontal cortex'. Together they form a unique fingerprint.

Cite this