Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insects

Cornelia Schönbauer, Jutta Distler, Nina Jährling, Martin Radolf, Hans Ulrich Dodt, Manfred Frasch, Frank Schnorrer

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Flying insects oscillate their wings at high frequencies of up to 1,000 Hz and produce large mechanical forces of 80ĝ€‰W per kilogram of muscle. They utilize a pair of perpendicularly oriented indirect flight muscles that contain fibrillar, stretch-activated myofibres. In contrast, all other, more slowly contracting, insect body muscles have a tubular muscle morphology. Here we identify the transcription factor Spalt major (Salm) as a master regulator of fibrillar flight muscle fate in Drosophila. salm is necessary and sufficient to induce fibrillar muscle fate. salm switches the entire transcriptional program from tubular to fibrillar fate by regulating the expression and splicing of key sarcomeric components specific to each muscle type. Spalt function is conserved in insects evolutionarily separated by 280 million years. We propose that Spalt proteins switch myofibres from tubular to fibrillar fate during development, a function potentially conserved in the vertebrate heart-a stretch-activated muscle sharing features with insect flight muscle.

Original languageEnglish
Pages (from-to)406-409
Number of pages4
JournalNature
Volume479
Issue number7373
DOIs
StatePublished - 17 Nov 2011
Externally publishedYes

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