Sox2 in the Dermal Papilla Niche Controls Hair Growth by Fine-Tuning BMP Signaling in Differentiating Hair Shaft Progenitors

Carlos Clavel, Laura Grisanti, Roland Zemla, Amelie Rezza, Rita Barros, Rachel Sennett, Amin Reza Mazloom, Chi Yeh Chung, Xiaoqiang Cai, Chen Leng Cai, Larysa Pevny, Silvia Nicolis, Avi Ma'ayan, Michael Rendl

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

How dermal papilla (DP) niche cells regulate hair follicle progenitors to control hair growth remains unclear. Using Tbx18Cre to target embryonic DP precursors, we ablate the transcription factor Sox2 early and efficiently, resulting in diminished hair shaft outgrowth. We find that DP niche expression of Sox2 controls the migration speed of differentiating hair shaft progenitors. Transcriptional profiling of Sox2 null DPs reveals increased Bmp6 and decreased BMP inhibitor Sostdc1, a direct Sox2 transcriptional target. Subsequently, we identify upregulated BMP signaling in knockout hair shaft progenitors and demonstrate that Bmp6 inhibits cell migration, an effect that can be attenuated by Sostdc1. A shorter and Sox2-negative hair type lacks Sostdc1 in the DP and shows reduced migration and increased BMP activity of hair shaft progenitors. Collectively, our data identify Sox2 as a key regulator of hair growth that controls progenitor migration by fine-tuning BMP-mediated mesenchymal-epithelial crosstalk. Mesenchymal-epithelial crosstalk is a prominent feature of hair follicle development and regeneration. Clavel et al. find that Sox2 regulates the ability of the dermal papilla niche to control hair shaft progenitor migration and thus hair outgrowth. Sox2 fine-tunes BMP signal output, which in turn attenuates progenitor migration rates.

Original languageEnglish
Pages (from-to)981-994
Number of pages14
JournalDevelopmental Cell
Volume23
Issue number5
DOIs
StatePublished - 13 Nov 2012

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