SOX17: escape route from immune destruction in early CRC

Kostas A. Papavassiliou; Christos Adamopoulos; Athanasios G. Papavassiliou

doi:10.1016/j.molmed.2024.04.001

SOX17: escape route from immune destruction in early CRC

Kostas A. Papavassiliou
, Christos Adamopoulos
, Athanasios G. Papavassiliou

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

In a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5^– (LGR5^–) tumor cells, which suppress interferon gamma (IFNγ) signaling and promote immune escape.

Original language	English
Pages (from-to)	609-611
Number of pages	3
Journal	Trends in Molecular Medicine
Volume	30
Issue number	7
DOIs	https://doi.org/10.1016/j.molmed.2024.04.001
State	Published - Jul 2024

Keywords

IFNγ
SOX17
colorectal adenoma
colorectal cancer
immune evasion

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10.1016/j.molmed.2024.04.001

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@article{cf23bbe0819a47db8dcbd4f83ca67f6b,

title = "SOX17: escape route from immune destruction in early CRC",

abstract = "In a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5– (LGR5–) tumor cells, which suppress interferon gamma (IFNγ) signaling and promote immune escape.",

keywords = "IFNγ, SOX17, colorectal adenoma, colorectal cancer, immune evasion",

author = "Papavassiliou, \{Kostas A.\} and Christos Adamopoulos and Papavassiliou, \{Athanasios G.\}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = jul,

doi = "10.1016/j.molmed.2024.04.001",

language = "English",

volume = "30",

pages = "609--611",

journal = "Trends in Molecular Medicine",

issn = "1471-4914",

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number = "7",

}

TY - JOUR

T1 - SOX17

T2 - escape route from immune destruction in early CRC

AU - Papavassiliou, Kostas A.

AU - Adamopoulos, Christos

AU - Papavassiliou, Athanasios G.

PY - 2024/7

Y1 - 2024/7

N2 - In a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5– (LGR5–) tumor cells, which suppress interferon gamma (IFNγ) signaling and promote immune escape.

AB - In a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5– (LGR5–) tumor cells, which suppress interferon gamma (IFNγ) signaling and promote immune escape.

KW - IFNγ

KW - SOX17

KW - colorectal adenoma

KW - colorectal cancer

KW - immune evasion

UR - https://www.scopus.com/pages/publications/85189769064

U2 - 10.1016/j.molmed.2024.04.001

DO - 10.1016/j.molmed.2024.04.001

M3 - Short survey

AN - SCOPUS:85189769064

SN - 1471-4914

VL - 30

SP - 609

EP - 611

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 7

ER -

SOX17: escape route from immune destruction in early CRC

Abstract

Keywords

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