Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis

Scott A. Small, Sam Gandy

Research output: Contribution to journalReview articlepeer-review

255 Scopus citations

Abstract

During the first 100 years of Alzheimer's disease research, this devastating and intractable disorder has been characterized at the clinical, histological, and molecular levels. Nevertheless, many key mechanistic questions remain unanswered. Here we will emphasize the importance of the cell biology of Alzheimer's disease, reviewing the relevant literature that has expanded our mechanistic understanding, with a particular focus on pathways regulating protein sorting. Accumulated evidence indicates that sorting pathways may be uniquely vulnerable to disease pathogenesis, and recent studies have begun to reveal disease-related defects in the regulation of protein sorting.

Original languageEnglish
Pages (from-to)15-31
Number of pages17
JournalNeuron
Volume52
Issue number1
DOIs
StatePublished - 5 Oct 2006
Externally publishedYes

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