TY - JOUR
T1 - Sorting through the Cell Biology of Alzheimer's Disease
T2 - Intracellular Pathways to Pathogenesis
AU - Small, Scott A.
AU - Gandy, Sam
N1 - Funding Information:
The authors would like to acknowledge the support of the McKnight Foundation (S.A.S.), the McDonnell Foundation (S.A.S.), the Farber Family Foundation (S.G.), and the National Institutes of Health, including P50 AG08702 and RO1 AG025161 (S.A.S.), R01 AG023611 (S.G.), R01 NS41017 (S.G.), and P01 AG10491 (S.G.). We also thank Huaxi Xu, Rick Kahn, and Allan Levey for helpful discussions, and we thank Jennifer Gropper for administrative support.
PY - 2006/10/5
Y1 - 2006/10/5
N2 - During the first 100 years of Alzheimer's disease research, this devastating and intractable disorder has been characterized at the clinical, histological, and molecular levels. Nevertheless, many key mechanistic questions remain unanswered. Here we will emphasize the importance of the cell biology of Alzheimer's disease, reviewing the relevant literature that has expanded our mechanistic understanding, with a particular focus on pathways regulating protein sorting. Accumulated evidence indicates that sorting pathways may be uniquely vulnerable to disease pathogenesis, and recent studies have begun to reveal disease-related defects in the regulation of protein sorting.
AB - During the first 100 years of Alzheimer's disease research, this devastating and intractable disorder has been characterized at the clinical, histological, and molecular levels. Nevertheless, many key mechanistic questions remain unanswered. Here we will emphasize the importance of the cell biology of Alzheimer's disease, reviewing the relevant literature that has expanded our mechanistic understanding, with a particular focus on pathways regulating protein sorting. Accumulated evidence indicates that sorting pathways may be uniquely vulnerable to disease pathogenesis, and recent studies have begun to reveal disease-related defects in the regulation of protein sorting.
UR - http://www.scopus.com/inward/record.url?scp=33749042749&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2006.09.001
DO - 10.1016/j.neuron.2006.09.001
M3 - Review article
C2 - 17015224
AN - SCOPUS:33749042749
SN - 0896-6273
VL - 52
SP - 15
EP - 31
JO - Neuron
JF - Neuron
IS - 1
ER -