Sometimes it takes darkness to see the light: Pitfalls in the interpretation of cell proliferation markers (Ki-67 and PCNA)

Carmen Castilla, Patrick McDonough, Gizem Tumer, Peter C. Lambert, W. Clark Lambert

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The degree of cell proliferation in a tumor is often associated with metastatic risk and mortality. Proliferating cell nuclear antigen (PCNA) and Ki-67 are proliferation markers that can be used to assess malignant potential in cutaneous lesions and pathological cell proliferation in psoriasis. These markers are elevated during periods of cell proliferation; however, they are also upregulated following UV irradiation. This up regulation may be problematic, as many skin lesions are subject to sun exposure in an everyday setting.

Original languageEnglish
Pages (from-to)90-92
Number of pages3
JournalSkinmed
Volume10
Issue number2
StatePublished - 1 Mar 2012
Externally publishedYes

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