Soluble Levels of Receptor for Advanced Glycation Endproducts (RAGE) and Progression of Atherosclerosis in Individuals Infected with Human Immunodeficiency Virus: ACTG NWCS 332

Ann Danoff, Michelle A. Kendall, Judith S. Currier, Theodoros Kelesidis, Ann Marie Schmidt, Judith A. Aberg

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Identification of biomarkers and/or mediators of cardiovascular disease (CVD) associated with HIV infection would be of diagnostic and therapeutic value. As soluble receptor for advanced glycation endproducts (sRAGE) and endogenous secretory (esRAGE) have been implicated in vascular complications in other settings, we investigated whether either soluble form of RAGE was associated with changes in carotid intima-media thickness (CIMT) in HIV-infected patients and HIV-uninfected controls. We found no differences in sRAGE, esRAGE, or CIMT among groups at study entry, or in yearly rates of change in sRAGE, esRAGE, or CIMT by HIV-serostatus (all p > 0.10). However, yearly rates of change in sRAGE (p = 0.07) and esRAGE (p < 0.001) were higher in those taking protease inhibitors, and lower baseline esRAGE levels (p = 0.06) were associated with increased odds of CIMT progression in HIV-infected individuals. Although esRAGE was not altered by HIV-serostatus (p = 0.17), its inverse relationship with CIMT progression in HIV-infected patients suggests a possible role as a mediator of CVD in HIV-infected persons.

Original languageEnglish
Pages (from-to)1354-1362
Number of pages9
JournalInflammation
Volume39
Issue number4
DOIs
StatePublished - 1 Aug 2016

Keywords

  • atherosclerosis
  • carotid intima-media thickness
  • human immunodeficiency virus
  • receptor of advanced glycation endproducts

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