TY - JOUR
T1 - Solid tumours hijack the histone variant network
AU - Ghiraldini, Flávia G.
AU - Filipescu, Dan
AU - Bernstein, Emily
N1 - Funding Information:
The authors thank members of the Bernstein laboratory for discussions relevant to this Review. This work was supported by NIH/NCI grant R01CA154683, NIH/NCI grant R01CA218024, NIH/NINDS grant R01NS110837 (E.B.) and the American Skin Association Ping Y. Tai Foundation Research Grant in Skin Cancer/Melanoma (D.F.). The authors apologize to those whose work was not cited due to space constraints.
Publisher Copyright:
© 2021, Springer Nature Limited.
PY - 2021/4
Y1 - 2021/4
N2 - Cancer is a complex disease characterized by loss of cellular homeostasis through genetic and epigenetic alterations. Emerging evidence highlights a role for histone variants and their dedicated chaperones in cancer initiation and progression. Histone variants are involved in processes as diverse as maintenance of genome integrity, nuclear architecture and cell identity. On a molecular level, histone variants add a layer of complexity to the dynamic regulation of transcription, DNA replication and repair, and mitotic chromosome segregation. Because these functions are critical to ensure normal proliferation and maintenance of cellular fate, cancer cells are defined by their capacity to subvert them. Hijacking histone variants and their chaperones is emerging as a common means to disrupt homeostasis across a wide range of cancers, particularly solid tumours. Here we discuss histone variants and histone chaperones as tumour-promoting or tumour-suppressive players in the pathogenesis of cancer.
AB - Cancer is a complex disease characterized by loss of cellular homeostasis through genetic and epigenetic alterations. Emerging evidence highlights a role for histone variants and their dedicated chaperones in cancer initiation and progression. Histone variants are involved in processes as diverse as maintenance of genome integrity, nuclear architecture and cell identity. On a molecular level, histone variants add a layer of complexity to the dynamic regulation of transcription, DNA replication and repair, and mitotic chromosome segregation. Because these functions are critical to ensure normal proliferation and maintenance of cellular fate, cancer cells are defined by their capacity to subvert them. Hijacking histone variants and their chaperones is emerging as a common means to disrupt homeostasis across a wide range of cancers, particularly solid tumours. Here we discuss histone variants and histone chaperones as tumour-promoting or tumour-suppressive players in the pathogenesis of cancer.
UR - http://www.scopus.com/inward/record.url?scp=85101045384&partnerID=8YFLogxK
U2 - 10.1038/s41568-020-00330-0
DO - 10.1038/s41568-020-00330-0
M3 - Review article
C2 - 33568791
AN - SCOPUS:85101045384
SN - 1474-175X
VL - 21
SP - 257
EP - 275
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 4
ER -